Seroatlas · Human Serome Atlas

ARPC2

Actin-related protein 2/3 complex subunit 2

Also known as: ARC34, ARPC2_HUMAN, p34-Arc

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15144
Gene
ARPC2
Ensembl
ENSG00000163466
Chromosome
2
Canonical length
300 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>O15144|ARPC2
     1  MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG DKTKVMVSIS
    61  LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE NLPASKDSIV HQAGMLKRNC
   121  FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE TMYVESKKDR VTVVFSTVFK DDDDVVIGKV
   181  FMQEFKEGRR ASHTAPQVLF SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT
   241  INLIHTFRDY LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARPC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
586 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 586 nTPM
  • bone marrow: 514 nTPM
  • esophagus: 474 nTPM
  • lymph node: 472 nTPM
  • urinary bladder: 376 nTPM
  • skeletal muscle: 361 nTPM

Single-cell type

  • esophageal apical cells: 3,043 nCPM
  • extravillous trophoblasts: 2,093 nCPM
  • esophageal suprabasal cells: 2,017 nCPM
  • neutrophils: 1,912 nCPM
  • syncytiotrophoblasts: 1,297 nCPM
  • migrating cytotrophoblasts: 1,284 nCPM

Immune cell

  • total PBMC: 2,502 nTPM
  • neutrophil: 2,209 nTPM
  • non-classical monocyte: 2,069 nTPM
  • eosinophil: 1,980 nTPM
  • intermediate monocyte: 1,775 nTPM
  • basophil: 1,734 nTPM

Brain region

  • hippocampal formation: 120 nTPM
  • cerebral cortex: 110 nTPM
  • white matter: 101 nTPM
  • basal ganglia: 99 nTPM
  • hypothalamus: 96 nTPM
  • spinal cord: 86 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
2.7
DepMap mean gene effect
-0.53
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARPC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARPC2 as an antibody target. Whether an autoantibody or antibody against ARPC2 could matter depends on whether native ARPC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARPC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARPC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARPC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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