ARPC5L
Actin-related protein 2/3 complex subunit 5-like protein
Also known as: ARC16-2, ARP5L_HUMAN, MGC3038
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BPX5
- Gene
- ARPC5L
- Ensembl
- ENSG00000136950
- Chromosome
- 9
- Canonical length
- 153 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Located in extracellular exosome and focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
153 residues, UniProt reviewed canonical sequence.
>Q9BPX5|ARPC5L
1 MARNTLSSRF RRVDIDEFDE NKFVDEQEEA AAAAAEPGPD PSEVDGLLRQ GDMLRAFHAA
61 LRNSPVNTKN QAVKERAQGV VLKVLTNFKS SEIEQAVQSL DRNGVDLLMK YIYKGFEKPT
121 ENSSAVLLQW HEKALAVGGL GSIIRVLTAR KTVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ARPC5L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 89 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 89 nTPM
- cerebral cortex: 86 nTPM
- testis: 76 nTPM
- amygdala: 73 nTPM
- basal ganglia: 68 nTPM
- skeletal muscle: 68 nTPM
Single-cell type
- late spermatids: 1,392 nCPM
- esophageal apical cells: 792 nCPM
- early spermatids: 581 nCPM
- late primary spermatocytes: 497 nCPM
- esophageal suprabasal cells: 458 nCPM
- suprabasal keratinocytes: 334 nCPM
Immune cell
- NK-cell: 87 nTPM
- memory CD8 T-cell: 78 nTPM
- gdT-cell: 73 nTPM
- MAIT T-cell: 72 nTPM
- memory B-cell: 68 nTPM
- naive B-cell: 65 nTPM
Brain region
- cerebral cortex: 42 nTPM
- hippocampal formation: 37 nTPM
- basal ganglia: 34 nTPM
- white matter: 32 nTPM
- hypothalamus: 32 nTPM
- pons: 29 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.72
- gnomAD pLI
- 0.55
- gnomAD missense Z
- 1.24
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ARPC5L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ARPC5L as an antibody target. Whether an autoantibody or antibody against ARPC5L could matter depends on whether native ARPC5L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ARPC5L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ARPC5L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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