Seroatlas · Human Serome Atlas

MTPN

Myotrophin

Also known as: GCDP, MTPN_HUMAN, MYOTROPHIN, V-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P58546
Gene
MTPN
Ensembl
ENSG00000105887
Chromosome
7
Canonical length
118 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>P58546|MTPN
     1  MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD
    61  INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD GLTAFEATDN QAIKALLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTPN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
143 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 143 nTPM
  • esophagus: 115 nTPM
  • cerebral cortex: 102 nTPM
  • tonsil: 101 nTPM
  • lymph node: 84 nTPM
  • basal ganglia: 83 nTPM

Single-cell type

  • platelets: 1,975 nCPM
  • esophageal apical cells: 1,409 nCPM
  • megakaryocytes: 754 nCPM
  • neutrophils: 687 nCPM
  • esophageal suprabasal cells: 512 nCPM
  • neutrophil progenitors: 499 nCPM

Immune cell

  • neutrophil: 181 nTPM
  • non-classical monocyte: 170 nTPM
  • naive B-cell: 125 nTPM
  • basophil: 118 nTPM
  • memory B-cell: 108 nTPM
  • intermediate monocyte: 106 nTPM

Brain region

  • hippocampal formation: 156 nTPM
  • medulla oblongata: 153 nTPM
  • basal ganglia: 147 nTPM
  • cerebral cortex: 142 nTPM
  • thalamus: 129 nTPM
  • amygdala: 127 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.82
gnomAD missense Z
1.68
DepMap mean gene effect
0.17
DepMap dependency class
none

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTPN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTPN as an antibody target. Whether an autoantibody or antibody against MTPN could matter depends on whether native MTPN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTPN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTPN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MTPN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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