Seroatlas · Human Serome Atlas

CAPZA1

F-actin-capping protein subunit alpha-1

Also known as: CAZA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52907
Gene: CAPZA1
Ensembl: ENSG00000116489
Chromosome: 1
Canonical length: 286 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

286 residues, UniProt reviewed canonical sequence.

>P52907|CAPZA1
     1  MADFDDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNMD
    61  QFTPVKIEGY EDQVLITEHG DLGNSRFLDP RNKISFKFDH LRKEASDPQP EEADGGLKSW
   121  RESCDSALRA YVKDHYSNGF CTVYAKTIDG QQTIIACIES HQFQPKNFWN GRWRSEWKFT
   181  ITPPTAQVVG VLKIQVHYYE DGNVQLVSHK DVQDSLTVSN EAQTAKEFIK IIENAENEYQ
   241  TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPZA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 176 nTPM

Expression across tissuesHPA

Tissue

tonsil: 176 nTPM
bone marrow: 148 nTPM
lymph node: 144 nTPM
esophagus: 120 nTPM
thymus: 110 nTPM
appendix: 109 nTPM

Single-cell type

neutrophils: 1,339 nCPM
esophageal apical cells: 741 nCPM
neutrophil progenitors: 709 nCPM
kupffer cells: 618 nCPM
early spermatids: 508 nCPM
monocytes: 497 nCPM

Immune cell

neutrophil: 527 nTPM
non-classical monocyte: 436 nTPM
basophil: 398 nTPM
intermediate monocyte: 386 nTPM
total PBMC: 370 nTPM
eosinophil: 320 nTPM

Brain region

white matter: 80 nTPM
medulla oblongata: 68 nTPM
thalamus: 67 nTPM
pons: 63 nTPM
hypothalamus: 63 nTPM
midbrain: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.93
gnomAD missense Z: 1.3
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAPZA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPZA1 as an antibody target. Whether an autoantibody or antibody against CAPZA1 could matter depends on whether native CAPZA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPZA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAPZA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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