EGF-like domain
PF00008
Definition
There is no clear separation between noise and signal. [pfam:PF00053] is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
69 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (69 proteins: gene, accession, name)
- AGRN
- BCAN
- CELSR1
- CELSR2
- CELSR3
- CNTNAP3
- CNTNAP3B
- CRB1
- CRB2
- CUBN
- DLK1
- DLK2
- DLL1
- DLL3
- DLL4
- DNER
- EDIL3
- EGF
- EGFL8
- EGFLAM
- EYS
- F10
- F12
- F7
- F9
- FAT1
- FAT2
- FAT3
- FAT4
- FBLN7
- HABP2
- HEG1
- HGFAC
- HSPG2
- JAG1
- JAG2
- LRP1B
- LTBP2
- MALRD1
- MEP1A
- MFGE8
- MMRN1
- NBPF26
- NCAN
- NOTCH1
- NOTCH2
- NOTCH2NLA
- NOTCH2NLB
- NOTCH2NLC
- NOTCH2NLR
- NOTCH3
- NOTCH4
- NRG1
- NRG4
- NRXN1
- PAMR1
- PLAT
- PROZ
- SELE
- SELL
- SLIT1
- SLIT2
- SLIT3
- SNED1
- SVEP1
- THBS4
- VASN
- VCAN
- VWA2
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