VASN

Protein identityUniProt · HPA

UniProt accession

Q6EMK4

Gene

VASN

Ensembl

ENSG00000168140

Chromosome

16

Canonical length

673 aa

Protein class

Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Nucleoli,Mitochondria

Secretome location

Secreted - unknown location

OverviewNCBI Gene

Enables transforming growth factor beta binding activity. Involved in negative regulation of epithelial to mesenchymal transition and negative regulation of transforming growth factor beta receptor signaling pathway. Located in cell surface and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

673 residues, UniProt reviewed canonical sequence.

>Q6EMK4|VASN
     1  MCSRVPLLLP LLLLLALGPG VQGCPSGCQC SQPQTVFCTA RQGTTVPRDV PPDTVGLYVF
    61  ENGITMLDAG SFAGLPGLQL LDLSQNQIAS LPSGVFQPLA NLSNLDLTAN RLHEITNETF
   121  RGLRRLERLY LGKNRIRHIQ PGAFDTLDRL LELKLQDNEL RALPPLRLPR LLLLDLSHNS
   181  LLALEPGILD TANVEALRLA GLGLQQLDEG LFSRLRNLHD LDVSDNQLER VPPVIRGLRG
   241  LTRLRLAGNT RIAQLRPEDL AGLAALQELD VSNLSLQALP GDLSGLFPRL RLLAAARNPF
   301  NCVCPLSWFG PWVRESHVTL ASPEETRCHF PPKNAGRLLL ELDYADFGCP ATTTTATVPT
   361  TRPVVREPTA LSSSLAPTWL SPTEPATEAP SPPSTAPPTV GPVPQPQDCP PSTCLNGGTC
   421  HLGTRHHLAC LCPEGFTGLY CESQMGQGTR PSPTPVTPRP PRSLTLGIEP VSPTSLRVGL
   481  QRYLQGSSVQ LRSLRLTYRN LSGPDKRLVT LRLPASLAEY TVTQLRPNAT YSVCVMPLGP
   541  GRVPEGEEAC GEAHTPPAVH SNHAPVTQAR EGNLPLLIAP ALAAVLLAAL AAVGAAYCVR
   601  RGRAMAAAAQ DKGQVGPGAG PLELEGVKVP LEPGPKATEG GGEALPSGSE CEVPLMGFPG
   661  PGLQSPLHAK PYI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VASN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

118 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.51

gnomAD pLI

0.67

gnomAD missense Z

0.29

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to hypoxia
• cellular response to redox state
• negative regulation of epithelial to mesenchymal transition
• negative regulation of transforming growth factor beta receptor signaling pathway

Molecular functions

• cadherin binding
• signaling receptor activity
• transforming growth factor beta binding

Cellular components

• cell surface
• extracellular exosome
• extracellular space
• lysosomal membrane
• mitochondrion
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat N-terminal domain
• Cysteine-rich flanking region, C-terminal
• EGF-like domain
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Fibronectin type III
• Immunoglobulin-like fold
• Leucine-rich repeat domain superfamily
• Fibronectin type III superfamily
• Leucine-rich repeat and transmembrane domain-containing protein
• EGF-like domain
• Leucine rich repeat

KeywordsUniProt

• Disulfide bond
• EGF-like domain
• Glycoprotein
• Leucine-rich repeat
• Membrane
• Repeat
• Secreted
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of VASN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TGFB1
• TGFB2
• TGFB3