Seroatlas · Human Serome Atlas

HABP2

Factor VII-activating protease

Also known as: FSAP, HABP, HABP2_HUMAN, HGFAL, PHBP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14520
Gene: HABP2
Ensembl: ENSG00000148702
Chromosome: 10
Canonical length: 560 aa
Protein class: Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>Q14520|HABP2
     1  MFARMSDLHV LLLMALVGKT ACGFSLMSLL ESLDPDWTPD QYDYSYEDYN QEENTSSTLT
    61  HAENPDWYYT EDQADPCQPN PCEHGGDCLV HGSTFTCSCL APFSGNKCQK VQNTCKDNPC
   121  GRGQCLITQS PPYYRCVCKH PYTGPSCSQV VPVCRPNPCQ NGATCSRHKR RSKFTCACPD
   181  QFKGKFCEIG SDDCYVGDGY SYRGKMNRTV NQHACLYWNS HLLLQENYNM FMEDAETHGI
   241  GEHNFCRNPD ADEKPWCFIK VTNDKVKWEY CDVSACSAQD VAYPEESPTE PSTKLPGFDS
   301  CGKTEIAERK IKRIYGGFKS TAGKHPWQAS LQSSLPLTIS MPQGHFCGGA LIHPCWVLTA
   361  AHCTDIKTRH LKVVLGDQDL KKEEFHEQSF RVEKIFKYSH YNERDEIPHN DIALLKLKPV
   421  DGHCALESKY VKTVCLPDGS FPSGSECHIS GWGVTETGKG SRQLLDAKVK LIANTLCNSR
   481  QLYDHMIDDS MICAGNLQKP GQDTCQGDSG GPLTCEKDGT YYVYGIVSWG LECGKRPGVY
   541  TQVTKFLNWI KATIKSESGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HABP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 409 nTPM

Expression across tissuesHPA

Tissue

liver: 409 nTPM
gallbladder: 34 nTPM
pancreas: 16 nTPM
kidney: 14 nTPM
stomach: 11 nTPM
heart muscle: 4 nTPM

Single-cell type

hepatocytes: 247 nCPM
cholangiocytes: 120 nCPM
oocytes: 83 nCPM
cardiomyocytes: 81 nCPM
pancreatic duct cells: 43 nCPM
gastric chief cells: 27 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2.3 nTPM
white matter: 1.1 nTPM
basal ganglia: 0.4 nTPM
thalamus: 0.4 nTPM
hippocampal formation: 0.3 nTPM
amygdala: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HABP2.

Disease | AllUniProt

Conditions HABP2 is implicated in, by any mechanism.

Thyroid cancer, non-medullary, 5 (NMTC5) MIM:616535

Disease | ImmuneIEDB

Conditions an epitope on HABP2 was assayed in.

rheumatoid arthritis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: -1.43
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HABP2 as an antibody target. Whether an autoantibody or antibody against HABP2 could matter depends on whether native HABP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HABP2 is annotated as secreted, so native HABP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HABP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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