Seroatlas · Human Serome Atlas

PAMR1

Inactive serine protease PAMR1

Also known as: DKFZP586H2123, PAMR1_HUMAN, RAMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UXH9
Gene
PAMR1
Ensembl
ENSG00000149090
Chromosome
11
Canonical length
720 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted - unknown location

OverviewNCBI Gene

Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

720 residues, UniProt reviewed canonical sequence.

>Q6UXH9|PAMR1
     1  MELGCWTQLG LTFLQLLLIS SLPREYTVIN EACPGAEWNI MCRECCEYDQ IECVCPGKRE
    61  VVGYTIPCCR NEENECDSCL IHPGCTIFEN CKSCRNGSWG GTLDDFYVKG FYCAECRAGW
   121  YGGDCMRCGQ VLRAPKGQIL LESYPLNAHC EWTIHAKPGF VIQLRFVMLS LEFDYMCQYD
   181  YVEVRDGDNR DGQIIKRVCG NERPAPIQSI GSSLHVLFHS DGSKNFDGFH AIYEEITACS
   241  SSPCFHDGTC VLDKAGSYKC ACLAGYTGQR CENLLEERNC SDPGGPVNGY QKITGGPGLI
   301  NGRHAKIGTV VSFFCNNSYV LSGNEKRTCQ QNGEWSGKQP ICIKACREPK ISDLVRRRVL
   361  PMQVQSRETP LHQLYSAAFS KQKLQSAPTK KPALPFGDLP MGYQHLHTQL QYECISPFYR
   421  RLGSSRRTCL RTGKWSGRAP SCIPICGKIE NITAPKTQGL RWPWQAAIYR RTSGVHDGSL
   481  HKGAWFLVCS GALVNERTVV VAAHCVTDLG KVTMIKTADL KVVLGKFYRD DDRDEKTIQS
   541  LQISAIILHP NYDPILLDAD IAILKLLDKA RISTRVQPIC LAASRDLSTS FQESHITVAG
   601  WNVLADVRSP GFKNDTLRSG VVSVVDSLLC EEQHEDHGIP VSVTDNMFCA SWEPTAPSDI
   661  CTAETGGIAA VSFPGRASPE PRWHLMGLVS WSYDKTCSHR LSTAFTKVLP FKDWIERNMK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAMR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • cervix: 56 nTPM
  • endometrium: 55 nTPM
  • placenta: 53 nTPM
  • vagina: 41 nTPM
  • adipose tissue: 32 nTPM
  • urinary bladder: 28 nTPM

Single-cell type

  • ependymal cells: 667 nCPM
  • astrocytes: 636 nCPM
  • adrenal medulla cells: 277 nCPM
  • breast myoepithelial cells: 209 nCPM
  • fibro-adipogenic progenitors: 144 nCPM
  • salivary myoepithelial cells: 143 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • spinal cord: 73 nTPM
  • medulla oblongata: 57 nTPM
  • white matter: 56 nTPM
  • midbrain: 52 nTPM
  • thalamus: 48 nTPM
  • basal ganglia: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
gnomAD missense Z
-0.46
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAMR1 as an antibody target. Whether an autoantibody or antibody against PAMR1 could matter depends on whether native PAMR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAMR1 is annotated as secreted, so native PAMR1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PAMR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PAMR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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