MALRD1

Protein identityUniProt · HPA

UniProt accession

Q5VYJ5

Gene

MALRD1

Ensembl

ENSG00000204740

Chromosome

10

Canonical length

2156 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Golgi apparatus

OverviewNCBI Gene

This gene encodes a conserved protein that features multiple MAM (meprin-A5-protein tyrosine phosphatase mu) and LDLR A2 (low density lipoprotein receptor A2) domains. Expression of this gene is enriched in the small intestine and is upregulated during differentiation of a human cell line that exhibits properties of intestinal epithelial cells. The encoded protein has been shown to modulate production of FGF19 in a human intestinal cell line and may regulate bile acid metabolism in the liver. A synergistic interaction between an allele of this gene and the APOE E4 allele is associated with an elevated risk of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

2156 residues, UniProt reviewed canonical sequence.

>Q5VYJ5|MALRD1
     1  MLFFLDRMLA FPMNETFCCL WIACVFNSTL AQQGTESFQC DNGVSLPPDS ICDFTDQCGD
    61  SSDERHCLNY ERCDFEDGLC HMTQDQSLQP SWTKRSGMIG LSPPFYDHNG DVSAHFLSLV
   121  SRVDSISSSL RSRVFLPTND QHDCQITFYY FSCQVSGKLM VGLQTACGGP IQHLWQNTAA
   181  LPNQWERNVI KIQSSQRFQV VFEGQMASTY EQDEVIAIDD ISFSSGCLPA NDGILLCQEA
   241  LNAERELCHP DTDLCRFDAT DEELRLCQAC GFEFDMCEWT SEASAGQISW MRTKAREIPA
   301  FESTPQQDQG GDDEGYYVWV GAKHGFTLNH LDSRAYLNSS VCHCLGKSCH LQFYYAMESS
   361  VLRVRLYNNK EEEIFWTYNI STHSQWVKAD VLIPEDLKTF KIIFEGTLLS QRSFIALDHL
   421  WVYACGQTQS RKLCSADEFP CTSGQCIAKE SVCDSRQDCS DESDEDPATC SKHLTCDFES
   481  GFCGWEPFLT EDSHWKLMKG LNNGEHHFPA ADHTANINHG SFIYLEAQRS PGVAKLGSPV
   541  LTKLLTASTP CQVQFWYHLS QHSNLSVFTR TSLDGNLQKQ GKIIRFSESQ WSHAKIDLIA
   601  EAGESTLPFQ LILEATVLSS NATVALDDIS VSQECEISYK SLPRTSTQSK FSKCDFEANS
   661  CDWFEAISGD HFDWIRSSQS ELSADFEHQA PPRDHSLNAS QGHFMFILKK SSSLWQVAKL
   721  QSPTFSQTGP GCILSFWFYN YGLSVGAAEL QLHMENSHDS TVIWRVLYNQ GKQWLEATIQ
   781  LGRLSQPFHL SLDKVSLGIY DGVSAIDDIR FENCTLPLPA ESCEGLDHFW CRHTRACIEK
   841  LRLCDLVDDC GDRTDEVNCA PELQCNFETG ICNWEQDAKD DFDWTRSQGP TPTLNTGPMK
   901  DNTLGTAKGH YLYIESSEPQ AFQDSAALLS PILNATDTKG CTFRFYYHMF GKRIYRLAIY
   961  QRIWSDSRGQ LLWQIFGNQG NRWIRKHLNI SSRQPFQILV EASVGDGFTG DIAIDDLSFM
  1021  DCTLYPGNLP ADLPTPPETS VPVTLPPHNC TDNEFICRSD GHCIEKMQKC DFKYDCPDKS
  1081  DEASCVMEVC SFEKRSLCKW YQPIPVHLLQ DSNTFRWGLG NGISIHHGEE NHRPSVDHTQ
  1141  NTTDGWYLYA DSSNGKFGDT ADILTPIISL TGPKCTLVFW THMNGATVGS LQVLIKKDNV
  1201  TSKLWAQTGQ QGAQWKRAEV FLGIRSHTQI VFRAKRGISY IGDVAVDDIS FQDCSPLLSP
  1261  ERKCTDHEFM CANKHCIAKD KLCDFVNDCA DNSDETTFIC RTSSGRCDFE FDLCSWKQEK
  1321  DEDFDWNLKA SSIPAAGTEP AADHTLGNSS GHYIFIKSLF PQQPMRAARI SSPVISKRSK
  1381  NCKIIFHYHM YGNGIGALTL MQVSVTNQTK VLLNLTVEQG NFWRREELSL FGDEDFQLKF
  1441  EGRVGKGQRG DIALDDIVLT ENCLSLHDSV QEELAVPLPT GFCPLGYREC HNGKCYRLEQ
  1501  SCNFVDNCGD NTDENECGSS CTFEKGWCGW QNSQADNFDW VLGVGSHQSL RPPKDHTLGN
  1561  ENGHFMYLEA TAVGLRGDKA HFRSTMWRES SAACTMSFWY FVSAKATGSI QILIKTEKGL
  1621  SKVWQESKQN PGNHWQKADI LLGKLRNFEV IFQGIRTRDL GGGAAIDDIE FKNCTTVGEI
  1681  SELCPEITDF LCRDKKCIAS HLLCDYKPDC SDRSDEAHCA HYTSTTGSCN FETSSGNWTT
  1741  ACSLTQDSED DLDWAIGSRI PAKALIPDSD HTPGSGQHFL YVNSSGSKEG SVARITTSKS
  1801  FPASLGMCTV RFWFYMIDPR SMGILKVYTI EESGLNILVW SVIGNKRTGW TYGSVPLSSN
  1861  SPFKVAFEAD LDGNEDIFIA LDDISFTPEC VTGGPVPVQP SPCEADQFSC IYTLQCVPLS
  1921  GKCDGHEDCI DGSDEMDCPL SPTPPLCSNM EFPCSTDECI PSLLLCDGVP DCHFNEDELI
  1981  CSNKSCSNGA LVCASSNSCI PAHQRCDGFA DCMDFQLDES SCSECPLNYC RNGGTCVVEK
  2041  NGPMCRCRQG WKGNRCHIKF NPPATDFTYA QNNTWTLLGI GLAFLMTHIT VAVLCFLANR
  2101  KVPIRKTEGS GNCAFVNPVY GNWSNPEKTE SSVYSFSNPL YGTTSGSLET LSHHLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MALRD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

29 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.85

gnomAD pLI

0

gnomAD missense Z

0.3

OntologyGO

Biological processes

• cholesterol homeostasis
• negative regulation of bile acid biosynthetic process

Cellular components

• cytoplasmic vesicle membrane
• Golgi apparatus

Protein domainsUniProt · Pfam · InterPro

• EGF-like domain
• MAM domain
• Low-density lipoprotein (LDL) receptor class A repeat
• Concanavalin A-like lectin/glucanase domain superfamily
• Low-density lipoprotein (LDL) receptor class A, conserved site
• LDL receptor-like superfamily
• MAM domain-containing protein
• EGF-like domain
• Low-density lipoprotein receptor domain class A
• MAM domain, meprin/A5/mu

KeywordsUniProt

• Cytoplasmic vesicle
• Disulfide bond
• EGF-like domain
• Glycoprotein
• Membrane
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MALRD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FGF19