Seroatlas · Human Serome Atlas

EGFLAM

Pikachurin

Also known as: AGRINL, AGRNL, EGFLA_HUMAN, FLJ39155, PIKA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q63HQ2
Gene
EGFLAM
Ensembl
ENSG00000164318
Chromosome
5
Canonical length
1017 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted - unknown location

OverviewNCBI Gene

Predicted to enable calcium ion binding activity and glycosaminoglycan binding activity. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Part of cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1017 residues, UniProt reviewed canonical sequence.

>Q63HQ2|EGFLAM
     1  MDLIRGVLLR LLLLASSLGP GAVSLRAAIR KPGKVGPPLD IKLGALNCTA FSIQWKMPRH
    61  PGSPILGYTV FYSEVGADKS LQEQLHSVPL SRDIPTTEEV IGDLKPGTEY RVSIAAYSQA
   121  GKGRLSSPRH VTTLSQDSCL PPAAPQQPHV IVVSDSEVAL SWKPGASEGS APIQYYSVEF
   181  IRPDFDKKWT SIHERIQMDS MVIKGLDPDT NYQFAVRAMN SHGPSPRSWP SDIIRTLCPE
   241  EAGSGRYGPR YITDMGAGED DEGFEDDLDL DISFEEVKPL PATKGGNKKF LVESKKMSIS
   301  NPKTISRLIP PTSASLPVTT VAPQPIPIQR KGKNGVAIMS RLFDMPCDET LCSADSFCVN
   361  DYTWGGSRCQ CTLGKGGESC SEDIVIQYPQ FFGHSYVTFE PLKNSYQAFQ ITLEFRAEAE
   421  DGLLLYCGEN EHGRGDFMSL AIIRRSLQFR FNCGTGVAII VSETKIKLGG WHTVMLYRDG
   481  LNGLLQLNNG TPVTGQSQGQ YSKITFRTPL YLGGAPSAYW LVRATGTNRG FQGCVQSLAV
   541  NGRRIDMRPW PLGKALSGAD VGECSSGICD EASCIHGGTC TAIKADSYIC LCPLGFKGRH
   601  CEDAFTLTIP QFRESLRSYA ATPWPLEPQH YLSFMEFEIT FRPDSGDGVL LYSYDTGSKD
   661  FLSINLAGGH VEFRFDCGSG TGVLRSEDPL TLGNWHELRV SRTAKNGILQ VDKQKIVEGM
   721  AEGGFTQIKC NTDIFIGGVP NYDDVKKNSG VLKPFSGSIQ KIILNDRTIH VKHDFTSGVN
   781  VENAAHPCVR APCAHGGSCR PRKEGYDCDC PLGFEGLHCQ KECGNYCLNT IIEAIEIPQF
   841  IGRSYLTYDN PDILKRVSGS RSNVFMRFKT TAKDGLLLWR GDSPMRPNSD FISLGLRDGA
   901  LVFSYNLGSG VASIMVNGSF NDGRWHRVKA VRDGQSGKIT VDDYGARTGK SPGMMRQLNI
   961  NGALYVGGMK EIALHTNRQY MRGLVGCISH FTLSTDYHIS LVEDAVDGKN INTCGAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EGFLAM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
113 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 113 nTPM
  • skeletal muscle: 68 nTPM
  • retina: 62 nTPM
  • placenta: 49 nTPM
  • breast: 46 nTPM
  • adipose tissue: 39 nTPM

Single-cell type

  • cone photoreceptor cells: 1,159 nCPM
  • rod photoreceptor cells: 369 nCPM
  • pericytes: 330 nCPM
  • adrenal medulla cells: 330 nCPM
  • leydig cells: 161 nCPM
  • vascular smooth muscle cells: 79 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 7 nTPM
  • thalamus: 5.8 nTPM
  • pons: 5.6 nTPM
  • choroid plexus: 5.2 nTPM
  • basal ganglia: 3.3 nTPM
  • white matter: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
0.33
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EGFLAM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EGFLAM as an antibody target. Whether an autoantibody or antibody against EGFLAM could matter depends on whether native EGFLAM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EGFLAM is annotated as secreted, so native EGFLAM circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EGFLAM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EGFLAM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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