Seroatlas · Human Serome Atlas

HGFAC

Hepatocyte growth factor activator serine protease

Also known as: HGFA, HGFA_HUMAN, HGFAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q04756
Gene: HGFAC
Ensembl: ENSG00000109758
Chromosome: 4
Canonical length: 655 aa
Protein class: Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

655 residues, UniProt reviewed canonical sequence.

>Q04756|HGFAC
     1  MGRWAWVPSP WPPPGLGPFL LLLLLLLLLP RGFQPQPGGN RTESPEPNAT ATPAIPTILV
    61  TSVTSETPAT SAPEAEGPQS GGLPPPPRAV PSSSSPQAQA LTEDGRPCRF PFRYGGRMLH
   121  ACTSEGSAHR KWCATTHNYD RDRAWGYCVE ATPPPGGPAA LDPCASGPCL NGGSCSNTQD
   181  PQSYHCSCPR AFTGKDCGTE KCFDETRYEY LEGGDRWARV RQGHVEQCEC FGGRTWCEGT
   241  RHTACLSSPC LNGGTCHLIV ATGTTVCACP PGFAGRLCNI EPDERCFLGN GTGYRGVAST
   301  SASGLSCLAW NSDLLYQELH VDSVGAAALL GLGPHAYCRN PDNDERPWCY VVKDSALSWE
   361  YCRLEACESL TRVQLSPDLL ATLPEPASPG RQACGRRHKK RTFLRPRIIG GSSSLPGSHP
   421  WLAAIYIGDS FCAGSLVHTC WVVSAAHCFS HSPPRDSVSV VLGQHFFNRT TDVTQTFGIE
   481  KYIPYTLYSV FNPSDHDLVL IRLKKKGDRC ATRSQFVQPI CLPEPGSTFP AGHKCQIAGW
   541  GHLDENVSGY SSSLREALVP LVADHKCSSP EVYGADISPN MLCAGYFDCK SDACQGDSGG
   601  PLACEKNGVA YLYGIISWGD GCGRLHKPGV YTRVANYVDW INDRIRPPRR LVAPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HGFAC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 224 nTPM

Expression across tissuesHPA

Tissue

liver: 224 nTPM
testis: 3.8 nTPM
cerebellum: 1.7 nTPM
cerebral cortex: 0.8 nTPM
amygdala: 0.7 nTPM
pituitary gland: 0.7 nTPM

Single-cell type

late spermatids: 207 nCPM
hepatocytes: 91 nCPM
late primary spermatocytes: 91 nCPM
early spermatids: 88 nCPM
epididymal efferent duct ciliated cells: 30 nCPM
epididymal efferent duct absorptive cells: 23 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 4.4 nTPM
cerebral cortex: 4.4 nTPM
amygdala: 3 nTPM
hippocampal formation: 2.5 nTPM
basal ganglia: 2.2 nTPM
medulla oblongata: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: -0.58
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HGFAC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SPINT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HGFAC as an antibody target. Whether an autoantibody or antibody against HGFAC could matter depends on whether native HGFAC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HGFAC is annotated as secreted, so native HGFAC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HGFAC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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