NRG4
Pro-neuregulin-4, membrane-bound isoform
Also known as: HRG4, NRG4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WWG1
- Gene
- NRG4
- Ensembl
- ENSG00000169752
- Chromosome
- 15
- Canonical length
- 115 aa
- Protein class
- Predicted membrane proteins, Predicted secreted proteins
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>Q8WWG1|NRG4
1 MPTDHEEPCG PSHKSFCLNG GLCYVIPTIP SPFCRCVENY TGARCEEVFL PGSSIQTKSN
61 LFEAFVALAV LVTLIIGAFY FLCRKGHFQR ASSVQYDINL VETSSTSAHH SHEQHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NRG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 8.9 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 8.9 nTPM
- pancreas: 5 nTPM
- retina: 4 nTPM
- hypothalamus: 2.3 nTPM
- cerebral cortex: 1.9 nTPM
- pituitary gland: 1.9 nTPM
Single-cell type
- ependymal cells: 326 nCPM
- pancreatic acinar cells: 222 nCPM
- respiratory ciliated cells: 132 nCPM
- myonuclei: 126 nCPM
- foveolar cells: 114 nCPM
- rod photoreceptor cells: 111 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 8.8 nTPM
- cerebral cortex: 2.7 nTPM
- hypothalamus: 2.3 nTPM
- spinal cord: 2.2 nTPM
- pons: 2.1 nTPM
- medulla oblongata: 2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.33
- gnomAD pLI
- 0.03
- gnomAD missense Z
- 0.41
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NRG4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NRG4 as an antibody target. Whether an autoantibody or antibody against NRG4 could matter depends on whether native NRG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NRG4 is annotated at the cell surface, where native NRG4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label NRG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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