BTB-kelch protein
IPR017096
Definition
Proteins in this family contain an N-terminal BTB domain and the C-terminal Kelch motifs. The BTB/POZ domain facilitates protein binding. The Kelch motif is a 50-residue motif named after the Drosophila mutant in which it was first identified PMID:8453663. This sequence motif represents one β-sheet blade, and several of these repeats can associate to form a β-propeller. Some members in this family also contain a BACK domain, which is a conserved 130-residue region between the BTB domain and Kelch motifsPMID:15544948. BTB-kelch protein family includes KLHL and part of the KBTBD subfamilies, which encompass structurally related molecules that differ in the types and numbers of their protein domains. KBTBD subfamily typically possess a BTB and BACK domain and two to four Kelch motifs PMID:23676014. It's worth noting that not all the KBTBD subfamily members are in this entry.
44 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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