SANT/Myb domain
IPR001005
Definition
The myb/SANT domains can be classified into three groups: the myb-type HTH domain, which binds DNA, the SANT domain, which is a protein-protein interaction module, and the myb-like domain that can be involved in either of these functions. This entry represents a myb-like domain. The retroviral oncogene v-myb, and its cellular counterpart c-myb, encode nuclear DNA-binding proteins. In myb, one of the most conserved regions consisting of three tandem repeats has been shown to be involved in DNA-binding PMID:2824190. The SANT domain is present in nuclear receptor co-repressors and in the subunits of many chromatin-remodelling complexes PMID:8882580. It has a strong structural similarity to the DNA-binding domain of Myb-related proteins PMID:14536084. Both consist of tandem repeats of three α-helices that are arranged in a helix-turn-helix motif, each α-helix containing a bulky aromatic residue. Despite the overall similarity there are differences that indicate that the SANT domain is functionally divergent from the canonical Myb DNA-binding domain PMID:15040448.
46 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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