Seroatlas · Human Serome Atlas

ZZZ3

ZZ-type zinc finger-containing protein 3

Also known as: ATAC1, DKFZP564I052, ZZZ3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYH5
Gene: ZZZ3
Ensembl: ENSG00000036549
Chromosome: 1
Canonical length: 903 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

Enables histone reader activity; lysine-acetylated histone binding activity; and methylated histone binding activity. Involved in several processes, including chromatin organization; regulation of cell division; and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of ATAC complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

903 residues, UniProt reviewed canonical sequence.

>Q8IYH5|ZZZ3
     1  MAASRSTRVT RSTVGLNGLD ESFCGRTLRN RSIAHPEEIS SNSQVRSRSP KKRPEPVPIQ
    61  KGNNNGRTTD LKQQSTRESW VSPRKRGLSS SEKDNIERQA IENCERRQTE PVSPVLKRIK
   121  RCLRSEAPNS SEEDSPIKSD KESVEQRSTV VDNDADFQGT KRACRCLILD DCEKREIKKV
   181  NVSEEGPLNS AVVEEITGYL AVNGVDDSDS AVINCDDCQP DGNTKQNSIG SYVLQEKSVA
   241  ENGDTDTQTS MFLDSRKEDS YIDHKVPCTD SQVQVKLEDH KIVTACLPVE HVNQLTTEPA
   301  TGPFSETQSS LRDSEEEVDV VGDSSASKEQ CKENTNNELD TSLESMPASG EPEPSPVLDC
   361  VSAQMMSLSE PQEHRYTLRT SPRRAAPTRG SPTKNSSPYR ENGQFEENNL SPNETNATVS
   421  DNVSQSPTNP GEISQNEKGI CCDSQNNGSE GVSKPPSEAR LNIGHLPSAK ESASQHITEE
   481  EDDDPDVYYF ESDHVALKHN KDYQRLLQTI AVLEAQRSQA VQDLESLGRH QREALKNPIG
   541  FVEKLQKKAD IGLPYPQRVV QLPEIVWDQY THSLGNFERE FKNRKRHTRR VKLVFDKVGL
   601  PARPKSPLDP KKDGESLSYS MLPLSDGPEG SSSRPQMIRG RLCDDTKPET FNQLWTVEEQ
   661  KKLEQLLIKY PPEEVESRRW QKIADELGNR TAKQVASRVQ KYFIKLTKAG IPVPGRTPNL
   721  YIYSKKSSTS RRQHPLNKHL FKPSTFMTSH EPPVYMDEDD DRSCFHSHMN TAVEDASDDE
   781  SIPIMYRNLP EYKELLQFKK LKKQKLQQMQ AESGFVQHVG FKCDNCGIEP IQGVRWHCQD
   841  CPPEMSLDFC DSCSDCLHET DIHKEDHQLE PIYRSETFLD RDYCVSQGTS YNYLDPNYFP
   901  ANR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZZZ3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 19 nTPM
breast: 16 nTPM
liver: 16 nTPM
ovary: 15 nTPM
kidney: 14 nTPM
thymus: 13 nTPM

Single-cell type

oligodendrocytes: 346 nCPM
thyrotrophs: 344 nCPM
adrenal cortex cells: 306 nCPM
lactotrophs: 255 nCPM
myonuclei: 245 nCPM
choroid plexus epithelial cells: 241 nCPM

Immune cell

T-reg: 10 nTPM
MAIT T-cell: 9.6 nTPM
naive CD4 T-cell: 9.5 nTPM
naive B-cell: 9.1 nTPM
naive CD8 T-cell: 8.6 nTPM
NK-cell: 7.8 nTPM

Brain region

white matter: 45 nTPM
basal ganglia: 35 nTPM
pons: 30 nTPM
hypothalamus: 30 nTPM
spinal cord: 29 nTPM
midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 1.67
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, ZZ-type
SANT/Myb domain
Homedomain-like superfamily
Myb domain
Zinc finger, ZZ-type superfamily
Myb-like DNA-binding domain
Zinc finger, ZZ type
ZZ-type zinc finger-containing protein 3
ZZZ3, zinc finger, ZZ-type

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZZZ3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZZZ3 as an antibody target. Whether an autoantibody or antibody against ZZZ3 could matter depends on whether native ZZZ3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZZZ3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZZZ3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...