Seroatlas · Human Serome Atlas

MIS18BP1

Mis18-binding protein 1

Also known as: C14orf106, FLJ11186, KIAA1903, KNL2, M18BP_HUMAN, M18BP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P0N0
Gene: MIS18BP1
Ensembl: ENSG00000129534
Chromosome: 14
Canonical length: 1132 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity. Predicted to be involved in cell division. Predicted to be located in nucleoplasm. Predicted to be part of CENP-A recruiting complex. Predicted to be active in chromosome, centromeric region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1132 residues, UniProt reviewed canonical sequence.

>Q6P0N0|MIS18BP1
     1  MIATPLKHSR IYLPPEASSQ RRNLPMDAIF FDSIPSGTLT PVKDLVKYQN SSLKLNDHKK
    61  NQFLKMTTFN NKNIFQSTML TEATTSNSSL DISAIKPNKD GLKNKANYES PGKIFLRMKE
   121  KVLRDKQEQP SRNSSLLEPQ KSGNNETFTP NRVEKKKLQH TYLCEEKENN KSFQSDDSSL
   181  RASVQGVPLE SSNNDIFLPV KQKIQCQQEK KAPLHNLTYE LPTLNQEQEN FLAVEARNKT
   241  LTRAQLAKQI FHSKESIVAT TKSKKDTFVL ESVDSADEQF QNTNAETLST NCIPIKNGSL
   301  LMVSDSERTT EGTSQQKVKE GNGKTVPGET GLPGSMKDTC KIVLATPRLH ITIPRRSKRN
   361  ISKLSPPRIF QTVTNGLKKN QVVQLQEWMI KSINNNTAIC VEGKLIDVTN IYWHSNVIIE
   421  RIEHNKLRTI SGNVYILKGM IDQISMKEAG YPNYLIRKFM FGFPENWKEH IDNFLEQLRA
   481  GEKNREKTKQ KQKTGRSVRD IRKSMKNDAR ENQTDTAQRA TTTYDFDCDN LELKSNKHSE
   541  SPGATELNMC HSNCQNKPTL RFPDDQVNNT IQNGGGDDLS NQELIGKKEY KMSSKKLKIG
   601  ERTNERIIKS QKQETTEELD VSIDILTSRE QFFSDEERKY MAINQKKAYI LVTPLKSRKV
   661  IEQRCMRYNL SAGTIKAVTD FVIPECQKKS PISKSMGTLE NTFEGHKSKN KEDCDERDLL
   721  TVNRKIKISN LEKEQMLTSD FKKNTRLLPK LKKIENQVAM SFYKHQSSPD LSSEESETEK
   781  EIKRKAEVKK TKAGNTKEAV VHLRKSTRNT SNIPVILEPE TEESENEFYI KQKKARPSVK
   841  ETLQKSGVRK EFPITEAVGS DKTNRHPLEC LPGLIQDKEW NEKELQKLHC AFASLPKHKP
   901  GFWSEVAAAV GSRSPEECQR KYMENPRGKG SQKHVTKKKP ANSKGQNGKR GDADQKQTIK
   961  ITAKVGTLKR KQQMREFLEQ LPKDDHDDFF STTPLQHQRI LLPSFQDSED DDDILPNMDK
  1021  NPTTPSSVIF PLVKTPQCQH VSPGMLGSIN RNDCDKYVFR MQKYHKSNGG IVWGNIKKKL
  1081  VETDFSTPTP RRKTPFNTDL GENSGIGKLF TNAVESLDEE EKDYYFSNSD SA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIS18BP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 39 nTPM
thymus: 23 nTPM
lymph node: 22 nTPM
tonsil: 20 nTPM
spleen: 14 nTPM
appendix: 13 nTPM

Single-cell type

monocyte progenitors: 490 nCPM
neutrophil progenitors: 415 nCPM
microglia: 315 nCPM
monocytes: 222 nCPM
erythrocyte progenitors: 221 nCPM
kupffer cells: 221 nCPM

Immune cell

basophil: 65 nTPM
non-classical monocyte: 54 nTPM
eosinophil: 36 nTPM
plasmacytoid DC: 31 nTPM
classical monocyte: 29 nTPM
intermediate monocyte: 29 nTPM

Brain region

white matter: 7.9 nTPM
pons: 7 nTPM
medulla oblongata: 6.8 nTPM
spinal cord: 6.1 nTPM
hypothalamus: 5.9 nTPM
thalamus: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: -0.28
DepMap mean gene effect: -0.88
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

SANT/Myb domain
Homedomain-like superfamily
SANT domain
SANT associated
KNL2-like
SANTA (SANT Associated)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MIS18BP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIS18BP1 as an antibody target. Whether an autoantibody or antibody against MIS18BP1 could matter depends on whether native MIS18BP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIS18BP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIS18BP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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