Seroatlas · Human Serome Atlas

CDC5L

Cell division cycle 5-like protein

Also known as: CDC5, CDC5L_HUMAN, CEF1, hCDC5, PCDC5RP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99459
Gene: CDC5L
Ensembl: ENSG00000096401
Chromosome: 6
Canonical length: 802 aa
Protein class: Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm
Quaternary structure: Homotetramer

OverviewNCBI Gene

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

802 residues, UniProt reviewed canonical sequence.

>Q99459|CDC5L
     1  MPRIMIKGGV WRNTEDEILK AAVMKYGKNQ WSRIASLLHR KSAKQCKARW YEWLDPSIKK
    61  TEWSREEEEK LLHLAKLMPT QWRTIAPIIG RTAAQCLEHY EFLLDKAAQR DNEEETTDDP
   121  RKLKPGEIDP NPETKPARPD PIDMDEDELE MLSEARARLA NTQGKKAKRK AREKQLEEAR
   181  RLAALQKRRE LRAAGIEIQK KRKRKRGVDY NAEIPFEKKP ALGFYDTSEE NYQALDADFR
   241  KLRQQDLDGE LRSEKEGRDR KKDKQHLKRK KESDLPSAIL QTSGVSEFTK KRSKLVLPAP
   301  QISDAELQEV VKVGQASEIA RQTAEESGIT NSASSTLLSE YNVTNNSVAL RTPRTPASQD
   361  RILQEAQNLM ALTNVDTPLK GGLNTPLHES DFSGVTPQRQ VVQTPNTVLS TPFRTPSNGA
   421  EGLTPRSGTT PKPVINSTPG RTPLRDKLNI NPEDGMADYS DPSYVKQMER ESREHLRLGL
   481  LGLPAPKNDF EIVLPENAEK ELEEREIDDT YIEDAADVDA RKQAIRDAER VKEMKRMHKA
   541  VQKDLPRPSE VNETILRPLN VEPPLTDLQK SEELIKKEMI TMLHYDLLHH PYEPSGNKKG
   601  KTVGFGTNNS EHITYLEHNP YEKFSKEELK KAQDVLVQEM EVVKQGMSHG ELSSEAYNQV
   661  WEECYSQVLY LPGQSRYTRA NLASKKDRIE SLEKRLEINR GHMTTEAKRA AKMEKKMKIL
   721  LGGYQSRAMG LMKQLNDLWD QIEQAHLELR TFEELKKHED SAIPRRLECL KEDVQRQQER
   781  EKELQHRYAD LLLEKETLKS KF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC5L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

tongue: 21 nTPM
bone marrow: 20 nTPM
parathyroid gland: 19 nTPM
liver: 18 nTPM
skeletal muscle: 17 nTPM
thymus: 14 nTPM

Single-cell type

late spermatids: 414 nCPM
early spermatids: 381 nCPM
megakaryocytes: 136 nCPM
erythrocyte progenitors: 136 nCPM
megakaryocyte progenitors: 127 nCPM
megakaryocyte-erythroid progenitors: 119 nCPM

Immune cell

basophil: 20 nTPM
neutrophil: 20 nTPM
non-classical monocyte: 18 nTPM
eosinophil: 18 nTPM
intermediate monocyte: 16 nTPM
NK-cell: 15 nTPM

Brain region

cerebellum: 21 nTPM
white matter: 18 nTPM
cerebral cortex: 17 nTPM
hippocampal formation: 16 nTPM
choroid plexus: 15 nTPM
medulla oblongata: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDC5L.

Disease | ImmuneIEDB

Conditions an epitope on CDC5L was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 2.78
DepMap mean gene effect: -1.67
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

SANT/Myb domain
Homedomain-like superfamily
Myb domain
Myb-like DNA-binding domain
Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal
Pre-mRNA splicing factor component CDC5L/Cef1, second SANT/myb-like domain
Pre-mRNA splicing factor component CDC5L/Cef1
pre-mRNA splicing factor component

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC5L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC5L as an antibody target. Whether an autoantibody or antibody against CDC5L could matter depends on whether native CDC5L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC5L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC5L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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