Seroatlas · Human Serome Atlas

CRAMP1

Protein cramped-like

Also known as: CRAMP1L, CRML_HUMAN, KIAA1426

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RY5
Gene: CRAMP1
Ensembl: ENSG00000007545
Chromosome: 16
Canonical length: 1269 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable chromatin binding activity. Predicted to be involved in pattern specification process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1269 residues, UniProt reviewed canonical sequence.

>Q96RY5|CRAMP1
     1  MTVKLGDGGS GEDGLKKLGK RAADEESLEG EGAGGADAAE ESSGTKRDEK TPRAGADGPP
    61  APPGAPQAPS PPQGSPQDQH HFLRSSVRPQ SKRPRKDPPS AVGSGNAGGS GPRGKGAEGG
   121  GSSSGNVSGV APAAPAGGSR SSSRNLGSSG GEKEEGKKVR RQWESWSTED KNTFFEGLYE
   181  HGKDFEAIQN NIALKYKKKG KPASMVKNKE QVRHFYYRTW HKITKYIDFD HVFSRGLKKS
   241  SQELYGLICY GELRKKIGGC MDDKNATKLN ELIQVGATTV RYKGRNLRIK APMCRALKKL
   301  CDPDGLSDEE DQKPVRLPLK VPIELQPRNN HAWARVQSLA QNPRLRMIVE LHRKVSSLIE
   361  FLKQKWALHE VRVRKTLEER QLQDSCSAPM QEKVTLHLFP GENCTLTPLP GVARVVHSKA
   421  FCTVHWQEGG RCKQSAKDAH VLPPAQILGI QSGQGTARGQ VKCPRSGAEG KGVGRPPPAA
   481  DALQSSGESS PESAPGEGAA LSLSSPDAPD RPPPRHQDTG PCLEKTPAEG RDSPTREPGA
   541  LPCACGQLPD LEDELSLLDP LPRYLKSCQD LIVPEQCRCA DTRPGSEQPP LGGAASPEVL
   601  APVSKEAADL APTGPSPRPG PGLLLDVCTK DLADAPAEEL QEKGSPAGPP PSQGQPAARP
   661  PKEVPASRLA QQLREEGWNL QTSESLTLAE VYLMMGKPSK LQLEYDWLGP GRQDPRPGSL
   721  PTALHKQRLL SCLLKLISTE VNPKLALEAN TISTASVRPA QEEQSMTPPG KVVTVSSRSP
   781  RCPRNQASLR SSKTFPPSSA PCSSGLRNPP RPLLVPGPSS TGSNDSDGGL FAVPTTLPPN
   841  SRHGKLFSPS KEAELTFRQH LNSISMQSDF FLPKPRKLRN RHLRKPLVVQ RTLLPRPSEN
   901  QSHNVCSFSI LSNSSVTGRG SFRPIQSSLT KAALSRPIVP KVLPPQATSH LASAIDLAAT
   961  SAGILSGNPL PALDTEGLSG ISPLSSDEVT GAISGQDSTG THQDGDTLPT VGGSDPFVSI
  1021  PSRPEQEPVA DSFQGSSVLS LSELPKAPLQ NGLSIPLSSS ESSSTRLSPP DVSALLDISL
  1081  PGPPEDALSQ GEPATHISDS IIEIAISSGQ YGEGVPLSPA KLNGSDSSKS LPSPSSSPQP
  1141  HWIASPTHDP QWYPSDSTDS SLSSLFASFI SPEKSRKMLP TPIGTNSGTS LLGPSLLDGN
  1201  SRDSFVSRSL ADVAEVVDSQ LVCMMNENSI DYISRFNDLA QELSIAEPGR REALFDGGGG
  1261  GPAVSDLSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRAMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 28 nTPM
testis: 23 nTPM
bone marrow: 13 nTPM
thyroid gland: 12 nTPM
ovary: 12 nTPM
pituitary gland: 12 nTPM

Single-cell type

somatotrophs: 16 nCPM
thyrotrophs: 16 nCPM
lactotrophs: 14 nCPM
choroid plexus epithelial cells: 13 nCPM
tuft cells: 12 nCPM
renal collecting duct intercalated cells: 11 nCPM

Immune cell

NK-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
basophil: 0.1 nTPM
classical monocyte: 0.1 nTPM
intermediate monocyte: 0.1 nTPM

Brain region

cerebellum: 44 nTPM
cerebral cortex: 28 nTPM
amygdala: 27 nTPM
white matter: 26 nTPM
hippocampal formation: 26 nTPM
basal ganglia: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.05
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRAMP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRAMP1 as an antibody target. Whether an autoantibody or antibody against CRAMP1 could matter depends on whether native CRAMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRAMP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRAMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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