Seroatlas · Human Serome Atlas

MYBL2

Myb-related protein B

Also known as: B-MYB, BMYB, MYBB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P10244
Gene: MYBL2
Ensembl: ENSG00000101057
Chromosome: 20
Canonical length: 700 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

700 residues, UniProt reviewed canonical sequence.

>P10244|MYBL2
     1  MSRRTRCEDL DELHYQDTDS DVPEQRDSKC KVKWTHEEDE QLRALVRQFG QQDWKFLASH
    61  FPNRTDQQCQ YRWLRVLNPD LVKGPWTKEE DQKVIELVKK YGTKQWTLIA KHLKGRLGKQ
   121  CRERWHNHLN PEVKKSCWTE EEDRIICEAH KVLGNRWAEI AKMLPGRTDN AVKNHWNSTI
   181  KRKVDTGGFL SESKDCKPPV YLLLELEDKD GLQSAQPTEG QGSLLTNWPS VPPTIKEEEN
   241  SEEELAAATT SKEQEPIGTD LDAVRTPEPL EEFPKREDQE GSPPETSLPY KWVVEAANLL
   301  IPAVGSSLSE ALDLIESDPD AWCDLSKFDL PEEPSAEDSI NNSLVQLQAS HQQQVLPPRQ
   361  PSALVPSVTE YRLDGHTISD LSRSSRGELI PISPSTEVGG SGIGTPPSVL KRQRKRRVAL
   421  SPVTENSTSL SFLDSCNSLT PKSTPVKTLP FSPSQFLNFW NKQDTLELES PSLTSTPVCS
   481  QKVVVTTPLH RDKTPLHQKH AAFVTPDQKY SMDNTPHTPT PFKNALEKYG PLKPLPQTPH
   541  LEEDLKEVLR SEAGIELIIE DDIRPEKQKR KPGLRRSPIK KVRKSLALDI VDEDVKLMMS
   601  TLPKSLSLPT TAPSNSSSLT LSGIKEDNSL LNQGFLQAKP EKAAVAQKPR SHFTTPAPMS
   661  SAWKTVACGG TRDQLFMQEK ARQLLGRLKP SHTSRTLILS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYBL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 87 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 87 nTPM
lymph node: 52 nTPM
tonsil: 50 nTPM
thymus: 31 nTPM
spleen: 27 nTPM
appendix: 23 nTPM

Single-cell type

erythrocyte progenitors: 172 nCPM
pdcs: 123 nCPM
plasma cells: 118 nCPM
monocyte progenitors: 66 nCPM
megakaryocyte progenitors: 62 nCPM
differentiating spermatogonia: 55 nCPM

Immune cell

plasmacytoid DC: 92 nTPM
memory B-cell: 2.7 nTPM
naive B-cell: 1.4 nTPM
T-reg: 1.3 nTPM
total PBMC: 0.8 nTPM
memory CD8 T-cell: 0.3 nTPM

Brain region

thalamus: 0.8 nTPM
cerebral cortex: 0.4 nTPM
choroid plexus: 0.3 nTPM
pons: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.12
gnomAD missense Z: 1.57
DepMap mean gene effect: -0.47
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYBL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYBL2 as an antibody target. Whether an autoantibody or antibody against MYBL2 could matter depends on whether native MYBL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYBL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYBL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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