Seroatlas · Human Serome Atlas

RCOR1

REST corepressor 1

Also known as: COREST, KIAA0071, RCOR, RCOR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKL0
Gene: RCOR1
Ensembl: ENSG00000089902
Chromosome: 14
Canonical length: 485 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q9UKL0|RCOR1
     1  MPAMVEKGPE VSGKRRGRNN AAASASAAAA SAAASAACAS PAATAASGAA ASSASAAAAS
    61  AAAAPNNGQN KSLAAAAPNG NSSSNSWEEG SSGSSSDEEH GGGGMRVGPQ YQAVVPDFDP
   121  AKLARRSQER DNLGMLVWSP NQNLSEAKLD EYIAIAKEKH GYNMEQALGM LFWHKHNIEK
   181  SLADLPNFTP FPDEWTVEDK VLFEQAFSFH GKTFHRIQQM LPDKSIASLV KFYYSWKKTR
   241  TKTSVMDRHA RKQKREREES EDELEEANGN NPIDIEVDQN KESKKEVPPT ETVPQVKKEK
   301  HSTQAKNRAK RKPPKGMFLS QEDVEAVSAN ATAATTVLRQ LDMELVSVKR QIQNIKQTNS
   361  ALKEKLDGGI EPYRLPEVIQ KCNARWTTEE QLLAVQAIRK YGRDFQAISD VIGNKSVVQV
   421  KNFFVNYRRR FNIDEVLQEW EAEHGKEETN GPSNQKPVKS PDNSIKMPEE EDEAPVLDVR
   481  YASAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCOR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 44 nTPM
esophagus: 32 nTPM
placenta: 20 nTPM
vagina: 19 nTPM
skin: 16 nTPM
cervix: 15 nTPM

Single-cell type

neutrophil progenitors: 998 nCPM
neutrophils: 805 nCPM
esophageal apical cells: 645 nCPM
suprabasal keratinocytes: 526 nCPM
esophageal suprabasal cells: 471 nCPM
ocular epithelial cells: 439 nCPM

Immune cell

neutrophil: 3.7 nTPM
basophil: 3.1 nTPM
eosinophil: 2.2 nTPM
non-classical monocyte: 1.8 nTPM
intermediate monocyte: 1.5 nTPM
myeloid DC: 1.5 nTPM

Brain region

hippocampal formation: 11 nTPM
cerebellum: 10 nTPM
thalamus: 10 nTPM
white matter: 10 nTPM
hypothalamus: 9.9 nTPM
cerebral cortex: 9.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RCOR1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 112 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Joubert syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.11
gnomAD pLI: 1
gnomAD missense Z: 1.87
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RCOR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCOR1 as an antibody target. Whether an autoantibody or antibody against RCOR1 could matter depends on whether native RCOR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCOR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCOR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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