Seroatlas · Human Serome Atlas

MIER3

Mesoderm induction early response protein 3

Also known as: DKFZp686L09111, DKFZp781I1119, FLJ35954, MIER3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3K6
Gene: MIER3
Ensembl: ENSG00000155545
Chromosome: 5
Canonical length: 550 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of protein-containing complex. Implicated in breast cancer and lung adenocarcinoma. Biomarker of breast cancer; invasive ductal carcinoma; and lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>Q7Z3K6|MIER3
     1  MAEASFGSSS PVGSLSSEDH DFDPTAEMLV HDYDDERTLE EEEMMDEGKN FSSEIEDLEK
    61  EGTMPLEDLL AFYGYEPTIP AVANSSANSS PSELADELPD MTLDKEEIAK DLLSGDDEET
   121  QSSADDLTPS VTSHETSDFF PRPLRSNTAC DGDKESEVED VETDSGNSPE DLRKEIMIGL
   181  QYQAEIPPYL GEYDGNEKVY ENEDQLLWCP DVVLESKVKE YLVETSLRTG SEKIMDRISA
   241  GTHTRDNEQA LYELLKCNHN IKEAIERYCC NGKASQEGMT AWTEEECRSF EHALMLFGKD
   301  FHLIQKNKVR TRTVAECVAF YYMWKKSERY DYFAQQTRFG KKRYNHHPGV TDYMDRLVDE
   361  TEALGGTVNA SALTSNRPEP IPDQQLNILN SFTASDLTAL TNSVATVCDP TDVNCLDDSF
   421  PPLGNTPRGQ VNHVPVVTEE LLTLPSNGES DCFNLFETGF YHSELNPMNM CSEESERPAK
   481  RLKMGIAVPE SFMNEVSVNN LGVDFENHTH HITSAKMAVS VADFGSLSAN ETNGFISAHA
   541  LHQHAALHSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIER3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

colon: 29 nTPM
duodenum: 21 nTPM
rectum: 21 nTPM
retina: 16 nTPM
testis: 15 nTPM
small intestine: 15 nTPM

Single-cell type

colonocytes: 105 nCPM
foveolar cells: 41 nCPM
sertoli cells: 37 nCPM
cardiomyocytes: 35 nCPM
pituicytes/fscs: 32 nCPM
thymic myoid cells: 29 nCPM

Immune cell

memory CD8 T-cell: 2 nTPM
eosinophil: 1.6 nTPM
intermediate monocyte: 1.6 nTPM
MAIT T-cell: 1.6 nTPM
plasmacytoid DC: 1.6 nTPM
naive CD4 T-cell: 1.5 nTPM

Brain region

cerebellum: 30 nTPM
white matter: 20 nTPM
basal ganglia: 15 nTPM
hypothalamus: 14 nTPM
medulla oblongata: 14 nTPM
cerebral cortex: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 2.07
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MIER3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIER3 as an antibody target. Whether an autoantibody or antibody against MIER3 could matter depends on whether native MIER3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIER3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIER3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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