Seroatlas · Human Serome Atlas

MYBL1

Myb-related protein A

Also known as: A-myb, AMYB, MYBA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P10243
Gene: MYBL1
Ensembl: ENSG00000185697
Chromosome: 8
Canonical length: 752 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

752 residues, UniProt reviewed canonical sequence.

>P10243|MYBL1
     1  MAKRSRSEDE DDDLQYADHD YEVPQQKGLK KLWNRVKWTR DEDDKLKKLV EQHGTDDWTL
    61  IASHLQNRSD FQCQHRWQKV LNPELIKGPW TKEEDQRVIE LVQKYGPKRW SLIAKHLKGR
   121  IGKQCRERWH NHLNPEVKKS SWTEEEDRII YEAHKRLGNR WAEIAKLLPG RTDNSIKNHW
   181  NSTMRRKVEQ EGYLQDGIKS ERSSSKLQHK PCAAMDHMQT QNQFYIPVQI PGYQYVSPEG
   241  NCIEHVQPTS AFIQQPFIDE DPDKEKKIKE LEMLLMSAEN EVRRKRIPSQ PGSFSSWSGS
   301  FLMDDNMSNT LNSLDEHTSE FYSMDENQPV SAQQNSPTKF LAVEANAVLS SLQTIPEFAE
   361  TLELIESDPV AWSDVTSFDI SDAAASPIKS TPVKLMRIQH NEGAMECQFN VSLVLEGKKN
   421  TCNGGNSEAV PLTSPNIAKF STPPAILRKK RKMRVGHSPG SELRDGSLND GGNMALKHTP
   481  LKTLPFSPSQ FFNTCPGNEQ LNIENPSFTS TPICGQKALI TTPLHKETTP KDQKENVGFR
   541  TPTIRRSILG TTPRTPTPFK NALAAQEKKY GPLKIVSQPL AFLEEDIREV LKEETGTDLF
   601  LKEEDEPAYK SCKQENTASG KKVRKSLVLD NWEKEESGTQ LLTEDISDMQ SENRFTTSLL
   661  MIPLLEIHDN RCNLIPEKQD INSTNKTYTL TKKKPNPNTS KVVKLEKNLQ SNCEWETVVY
   721  GKTEDQLIMT EQARRYLSTY TATSSTSRAL IL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYBL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

lymph node: 19 nTPM
tonsil: 15 nTPM
testis: 11 nTPM
blood vessel: 8.6 nTPM
spleen: 7.1 nTPM
appendix: 5.8 nTPM

Single-cell type

nk-cells: 260 nCPM
t-cells: 171 nCPM
cardiomyocytes: 62 nCPM
innate lymphoid cells: 58 nCPM
early primary spermatocytes: 49 nCPM
late primary spermatocytes: 28 nCPM

Immune cell

gdT-cell: 1.9 nTPM
MAIT T-cell: 1.3 nTPM
memory CD8 T-cell: 0.8 nTPM
NK-cell: 0.6 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM

Brain region

white matter: 8.8 nTPM
pons: 8 nTPM
medulla oblongata: 6.3 nTPM
basal ganglia: 5.8 nTPM
cerebellum: 5.6 nTPM
spinal cord: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.08
gnomAD pLI: 1
gnomAD missense Z: 2.13
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell differentiation
male meiosis I
mitotic cell cycle
positive regulation of DNA-templated transcription
positive regulation of transcription by RNA polymerase II
spermatogenesis
positive regulation of piRNA transcription

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYBL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYBL1 as an antibody target. Whether an autoantibody or antibody against MYBL1 could matter depends on whether native MYBL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYBL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYBL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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