Seroatlas · Human Serome Atlas

RCOR2

REST corepressor 2

Also known as: RCOR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZ40
Gene: RCOR2
Ensembl: ENSG00000167771
Chromosome: 11
Canonical length: 523 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles,Midbody

OverviewNCBI Gene

Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q8IZ40|RCOR2
     1  MPSVMEKPSA GSGILSRSRA KTVPNGGQPH SEDDSSEEEH SHDSMIRVGT NYQAVIPECK
    61  PESPARYSNK ELKGMLVWSP NHCVSDAKLD KYIAMAKEKH GYNIEQALGM LLWHKHDVEK
   121  SLADLANFTP FPDEWTVEDK VLFEQAFGFH GKCFQRIQQM LPDKLIPSLV KYYYSWKKTR
   181  SRTSVMDRQA RRLGGRKDKE DSDELEEGRG GVSEGEPDPA DPKREPLPSR PLNARPGPGK
   241  KEVQVSQYRH HPLRTRRRPP KGMYLSPEGL TAVSGSPDLA NLTLRGLDSQ LISLKRQVQS
   301  MKQTNSSLRQ ALEGGIDPLR PPEANTKFNS RWTTDEQLLA VQAIRRYGKD FGAIAEVIGN
   361  KTLTQVKTFF VSYRRRFNLE EVLQEWEAEQ DGAPGAPVPM EEARRGAPLP APALEEDDEV
   421  QITSVSTSVP RSVPPAPPPP PPPTSLSQPP PLLRPPLPTA PTLLRQPPPL QQGRFLQPRL
   481  APNQPPPPLI RPALAAPRHS ARPGPQPPPT LIGTPLEPPA PSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCOR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 6.2 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 6.2 nTPM
cerebellum: 5.9 nTPM
basal ganglia: 5 nTPM
blood vessel: 3.3 nTPM
retina: 3.2 nTPM
pituitary gland: 3 nTPM

Single-cell type

retinal bipolar cells: 25 nCPM
adrenal medulla cells: 11 nCPM
extravillous trophoblasts: 7.2 nCPM
neuroendocrine cells: 6.5 nCPM
syncytiotrophoblasts: 6.5 nCPM
megakaryocytes: 6.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 8.8 nTPM
basal ganglia: 7.7 nTPM
white matter: 5.9 nTPM
hippocampal formation: 5.5 nTPM
amygdala: 3.8 nTPM
cerebellum: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.21
gnomAD missense Z: 1.65
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RCOR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCOR2 as an antibody target. Whether an autoantibody or antibody against RCOR2 could matter depends on whether native RCOR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCOR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCOR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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