Seroatlas · Human Serome Atlas

DNAJC1

DnaJ homolog subfamily C member 1

Also known as: DNAJL1, DNJC1_HUMAN, ERdj1, MTJ1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KC8
Gene: DNAJC1
Ensembl: ENSG00000136770
Chromosome: 10
Canonical length: 554 aa
Protein class: Predicted membrane proteins, Transcription factors
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

The membrane protein encoded by this gene is a DNAJ-like heat shock protein that binds the molecular chaperone BiP. In addition, the encoded protein contains two SANT domains that have been shown to bind serpin alpha1-antichymotrypsin and inter-alpha trypsin inhibitor heavy chain 4. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

554 residues, UniProt reviewed canonical sequence.

>Q96KC8|DNAJC1
     1  MTAPCSQPAQ LPGRRQLGLV PFPPPPPRTP LLWLLLLLLA AVAPARGWES GDLELFDLVE
    61  EVQLNFYQFL GVQQDASSAD IRKAYRKLSL TLHPDKNKDE NAETQFRQLV AIYEVLKDDE
   121  RRQRYDDILI NGLPDWRQPV FYYRRVRKMS NAELALLLFI ILTVGHYAVV WSIYLEKQLD
   181  ELLSRKKREK KKKTGSKSVD VSKLGASEKN ERLLMKPQWH DLLPCKLGIW FCLTLKALPH
   241  LIQDAGQFYA KYKETRLKEK EDALTRTELE TLQKQKKVKK PKPEFPVYTP LETTYIQSYD
   301  HGTSIEEIEE QMDDWLENRN RTQKKQAPEW TEEDLSQLTR SMVKFPGGTP GRWEKIAHEL
   361  GRSVTDVTTK AKQLKDSVTC SPGMVRLSEL KSTVQNSRPI KTATTLPDDM ITQREDAEGV
   421  AAEEEQEGDS GEQETGATDA RPRRRKPARL LEATAKPEPE EKSRAKRQKD FDIAEQNESS
   481  DEESLRKERA RSAEEPWTQN QQKLLELALQ QYPRGSSDRW DKIARCVPSK SKEDCIARYK
   541  LLVELVQKKK QAKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 43 nTPM
salivary gland: 38 nTPM
pancreas: 37 nTPM
liver: 35 nTPM
choroid plexus: 29 nTPM
thyroid gland: 27 nTPM

Single-cell type

plasma cells: 775 nCPM
somatotrophs: 628 nCPM
early primary spermatocytes: 551 nCPM
rod photoreceptor cells: 446 nCPM
salivary acinar cells: 436 nCPM
corticotrophs: 429 nCPM

Immune cell

plasmacytoid DC: 40 nTPM
MAIT T-cell: 37 nTPM
gdT-cell: 36 nTPM
NK-cell: 34 nTPM
non-classical monocyte: 31 nTPM
memory CD8 T-cell: 29 nTPM

Brain region

choroid plexus: 25 nTPM
hypothalamus: 20 nTPM
white matter: 19 nTPM
medulla oblongata: 19 nTPM
spinal cord: 17 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC1 as an antibody target. Whether an autoantibody or antibody against DNAJC1 could matter depends on whether native DNAJC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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