MIER1

Protein identityUniProt · HPA

UniProt accession

Q8N108

Gene

MIER1

Ensembl

ENSG00000198160

Chromosome

1

Canonical length

512 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

Secretome location

Intracellular and membrane

OverviewNCBI Gene

This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>Q8N108|MIER1
     1  MAEPSVESSS PGGSATSDDH EFDPSADMLV HDFDDERTLE EEEMMEGETN FSSEIEDLAR
    61  EGDMPIHELL SLYGYGSTVR LPEEDEEEEE EEEEGEDDED ADNDDNSGCS GENKEENIKD
   121  SSGQEDETQS SNDDPSQSVA SQDAQEIIRP RRCKYFDTNS EVEEESEEDE DYIPSEDWKK
   181  EIMVGSMFQA EIPVGICRYK ENEKVYENDD QLLWDPEYLP EDKVIIFLKD ASRRTGDEKG
   241  VEAIPEGSHI KDNEQALYEL VKCNFDTEEA LRRLRFNVKA AREELSVWTE EECRNFEQGL
   301  KAYGKDFHLI QANKVRTRSV GECVAFYYMW KKSERYDFFA QQTRFGKKKY NLHPGVTDYM
   361  DRLLDESESA ASSRAPSPPP TASNSSNSQS EKEDGTVSTA NQNGVSSNGP GEILNKEEVK
   421  VEGLHINGPT GGNKKPLHAD MDTNGYETDN LTTDPKLAHM TARNENDFDE KSERPAKRRR
   481  VNSNGKESPG SSEFFQEAVS HGKFEELENT DD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

92 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.42

gnomAD pLI

0.29

gnomAD missense Z

1.54

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chromatin remodeling
• negative regulation of transcription by RNA polymerase II
• positive regulation of canonical NF-kappaB signal transduction
• regulation of DNA-templated transcription

Molecular functions

• histone deacetylase binding
• transcription corepressor activity

Cellular components

• cytoplasm
• nucleoplasm
• nucleus
• protein-containing complex
• transcription repressor complex

Protein domainsUniProt · Pfam · InterPro

• ELM2 domain
• SANT/Myb domain
• Homedomain-like superfamily
• SANT domain
• Mesoderm induction early response protein/metastasis-associated protein
• Mesoderm induction early response protein 1/3, C-terminal
• Myb-like DNA-binding domain
• ELM2 domain
• Mesoderm induction early response protein 1/3 C-terminal

KeywordsUniProt

• Cytoplasm
• Isopeptide bond
• Nucleus
• Phosphoprotein
• Repressor
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of MIER1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HDAC1
• HDAC2