Seroatlas · Human Serome Atlas

ZNF541

Zinc finger protein 541

Also known as: DKFZp434I1930, ZN541_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0D2
Gene: ZNF541
Ensembl: ENSG00000118156
Chromosome: 19
Canonical length: 1346 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable transcription corepressor activity. Predicted to be involved in male meiotic nuclear division and regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1346 residues, UniProt reviewed canonical sequence.

>Q9H0D2|ZNF541
     1  MDQYSLGDEG ALPSEMHLPS FSESQGLNCS DTLNRDLGPN TRGFLYAGLS GLDPDPSLPT
    61  PDMSSEVLED NLDTLSLYSG KDSDSVKLLE EYADSESQAS LQDLGLGVLK AKEADEGGRA
   121  TSGSARKGKR QHSSPQNPLL DCSLCGKVFS SASSLSKHYL THSQERKHVC KICSKAFKRQ
   181  DHLTGHMLTH QKTKPFVCIE QGCSKSYCDY RSLRRHYEVH HGLCILKEAP PEEEACGDSP
   241  HAHESAGQPP PSSLRSLVPP EARSPGSLLP HRDLLRRIVS SIVHQKTPSP GPAPAGASDS
   301  EGRNTACPCP ASSGSSSCTP AGPHAAPAAL DTELPEEPCL PQKEPATDVF TAPNSRAAEN
   361  GAPDPPEPEP DTALLQARST AECWPEGGSV PACLPLFRGQ TVPASSQPSS HSFQWLRNLP
   421  GCPKSKGNNV FVVHKPSAVP SREGSESGPG PSSGSPSEES PPGPGGGLED ALPFPAALLR
   481  VPAEAPSDPR SASGEDDPCA PKKVKVDCDS FLCQNPGEPG LQEAQKAGGL PADASPLFRQ
   541  LFLKSQEPLV SHEQMQVFQM ITKSQRIFSH AQVAAVSSQL PAPEGKPAAL RPLQGPWPQQ
   601  PPPLAPAVDS LHAGPGNPEA EGSPARRRKT TPGVPREASP GSTRRDAKGG LKVAAVPTPL
   661  AAPSLDPSRN PDISSLAKQL RSSKGTLDLE DIFPSTGQRQ TQLGGEEPPG ASLPGKQAPA
   721  ENGAASRITK GEKGPACSRG GGYRLLGNPR APRFSGFRKE KAKMDMCCAA SPSQVAMASF
   781  SSAGPPADPS KSKLTIFSRI QGGNIYRLPH PVKEENVAGR GNQQNGSPTD WTKPRSTFVC
   841  KNCSQMFYTE KGLSSHMCFH SDQWPSPRGK QEPQVFGTEF CKPLRQVLRP EGDRHSPPGT
   901  KKPLDPTAAA PLVVPQSIPV VPVTRHIGSM AMGQEKDGEE RDSKESSQQR KRKKRPPPST
   961  AGEPGPAGCH QSRLRSPMFL VDCLLKGLFQ CSPYTPPPML SPIREGSGVY FNTLCSTSTQ
  1021  ASPDQLISSM LDQVDGSFGI CVVKDDTKIS IEPHINIGSR FQAEIPELQE RSLAGTDEHV
  1081  ASLVWKPWGD MMISSETQDR VTELCNVACS SVMPGGGTNL ELALHCLHEA QGNVQVALET
  1141  LLLRGPHKPR THLLADYRYT GSDVWTPIEK RLFKKAFYAH KKDFYLIHKM IQTKTVAQCV
  1201  EYYYIWKKMI KFDCGRAPGL EKRVKREPEE VERTEEKVPC SPRERPSHHP TPKLKTKSYR
  1261  RESILSSSPN AGSKRTPELL GSAESQGIFP CRECERVFDK IKSRNAHMKR HRLQDHVEPI
  1321  IRVKWPVKPF QLKEEELGAD IGPLQW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF541 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
adrenal gland: 3.1 nTPM
ovary: 2.3 nTPM
adipose tissue: 1 nTPM
heart muscle: 0.8 nTPM
colon: 0.7 nTPM

Single-cell type

early primary spermatocytes: 164 nCPM
late primary spermatocytes: 45 nCPM
differentiating spermatogonia: 44 nCPM
epididymal efferent duct absorptive cells: 42 nCPM
undifferentiated spermatogonia: 39 nCPM
adrenal cortex cells: 28 nCPM

Immune cell

MAIT T-cell: 0.4 nTPM
memory CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 1.6 nTPM
pons: 1.3 nTPM
amygdala: 1.2 nTPM
basal ganglia: 1.1 nTPM
hippocampal formation: 1 nTPM
cerebellum: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF541.

Disease | ImmuneIEDB

Conditions an epitope on ZNF541 was assayed in.

hepatocellular carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 2.64
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF541 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF541 as an antibody target. Whether an autoantibody or antibody against ZNF541 could matter depends on whether native ZNF541 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF541 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF541 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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