Seroatlas · Human Serome Atlas

RCOR3

REST corepressor 3

Also known as: FLJ10876, RCOR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P2K3
Gene
RCOR3
Ensembl
ENSG00000117625
Chromosome
1
Canonical length
495 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable enzyme binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>Q9P2K3|RCOR3
     1  MRVGAEYQAR IPEFDPGATK YTDKDNGGML VWSPYHSIPD AKLDEYIAIA KEKHGYNVEQ
    61  ALGMLFWHKH NIEKSLADLP NFTPFPDEWT VEDKVLFEQA FSFHGKSFHR IQQMLPDKTI
   121  ASLVKYYYSW KKTRSRTSLM DRQARKLANR HNQGDSDDDV EETHPMDGND SDYDPKKEAK
   181  KEGNTEQPVQ TSKIGLGRRE YQSLQHRHHS QRSKCRPPKG MYLTQEDVVA VSCSPNAANT
   241  ILRQLDMELI SLKRQVQNAK QVNSALKQKM EGGIEEFKPP ESNQKINARW TTEEQLLAVQ
   301  GVRKYGKDFQ AIADVIGNKT VGQVKNFFVN YRRRFNLEEV LQEWEAEQGT QASNGDASTL
   361  GEETKSASNV PSGKSTDEEE EAQTPQAPRT LGPSPPAPSS TPTPTAPIAT LNQPPPLLRP
   421  TLPAAPALHR QPPPLQQQAR FIQPRPTLNQ PPPPLIRPAN SMPPRLNPRP VLSTVGGQQP
   481  PSLIGIQTDS QSSLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCOR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 59 nTPM
  • tongue: 48 nTPM
  • testis: 31 nTPM
  • bone marrow: 30 nTPM
  • thyroid gland: 30 nTPM
  • retina: 28 nTPM

Single-cell type

  • myonuclei: 540 nCPM
  • cardiomyocytes: 212 nCPM
  • retinal ganglion cells: 201 nCPM
  • late spermatids: 197 nCPM
  • neutrophils: 169 nCPM
  • platelets: 168 nCPM

Immune cell

  • eosinophil: 46 nTPM
  • basophil: 28 nTPM
  • neutrophil: 21 nTPM
  • NK-cell: 20 nTPM
  • naive CD4 T-cell: 16 nTPM
  • memory B-cell: 15 nTPM

Brain region

  • cerebellum: 63 nTPM
  • white matter: 62 nTPM
  • cerebral cortex: 51 nTPM
  • basal ganglia: 50 nTPM
  • medulla oblongata: 48 nTPM
  • pons: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
2.72
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RCOR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCOR3 as an antibody target. Whether an autoantibody or antibody against RCOR3 could matter depends on whether native RCOR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCOR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCOR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RCOR3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...