Seroatlas · Human Serome Atlas

BACC1

BPTF-associated chromatin complex component 1

Also known as: BAP18, BAP18_HUMAN, C17orf49, HEPIS, MGC49942

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXM2
Gene: BACC1
Ensembl: ENSG00000258315
Chromosome: 17
Canonical length: 172 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in chromatin organization. Located in cytosol and nucleoplasm. Part of MLL1 complex and NURF complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>Q8IXM2|BACC1
     1  MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVADSSPAGA KWTETEIEML RAAVKRFGDD
    61  LNHISCVIKE RTVAQIKATV KRKVYEDSGI PLPAESPKKG PKKVASGVLS PPPAAPPPSS
   121  SSVPEAGGPP IKKQKADVTL SALNDSDANS DVVDIEGLGE TPPAKKLNFD QA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BACC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 115 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 115 nTPM
tonsil: 99 nTPM
lymph node: 91 nTPM
thymus: 91 nTPM
spleen: 71 nTPM
skeletal muscle: 67 nTPM

Single-cell type

oligodendrocytes: 13 nCPM
other brain neurons: 12 nCPM
brain excitatory neurons: 10 nCPM
ependymal cells: 9.2 nCPM
oligodendrocyte progenitor cells: 9 nCPM
brain inhibitory neurons: 7.7 nCPM

Immune cell

NK-cell: 392 nTPM
plasmacytoid DC: 348 nTPM
basophil: 260 nTPM
myeloid DC: 252 nTPM
memory B-cell: 240 nTPM
intermediate monocyte: 226 nTPM

Brain region

thalamus: 44 nTPM
cerebral cortex: 41 nTPM
white matter: 41 nTPM
cerebellum: 40 nTPM
hypothalamus: 39 nTPM
amygdala: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0.07
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chromatin organization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BACC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BACC1 as an antibody target. Whether an autoantibody or antibody against BACC1 could matter depends on whether native BACC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BACC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BACC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...