Seroatlas · Human Serome Atlas

MIER2

Mesoderm induction early response protein 2

Also known as: KIAA1193, MIER2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N344
Gene
MIER2
Ensembl
ENSG00000105556
Chromosome
19
Canonical length
545 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables histone deacetylase binding activity. Contributes to histone deacetylase activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

545 residues, UniProt reviewed canonical sequence.

>Q8N344|MIER2
     1  MAEASSLGRQ SPRVVSCLEH SLCPGEPGLQ TTAVVSMGSG DHQFNLAEIL SQNYSVRGEC
    61  EEASRCPDKP KEELEKDFIS QSNDMPFDEL LALYGYEASD PISDRESEGG DVAPNLPDMT
   121  LDKEQIAKDL LSGEEEEETQ SSADDLTPSV TSHEASDLFP NRSGSRFLAD EDREPGSSAS
   181  SDTEEDSLPA NKCKKEIMVG PQFQADLSNL HLNRHCEKIY ENEDQLLWDP SVLPEREVEE
   241  FLYRAVKRRW HEMAGPQLPE GEAVKDSEQA LYELVKCNFN VEEALRRLRF NVKVIRDGLC
   301  AWSEEECRNF EHGFRVHGKN FHLIQANKVR TRSVGECVEY YYLWKKSERY DYFAQQTRLG
   361  RRKYVPSGTT DADQDLDGSD PDGPGRPRPE QDTLTGMRTD PLSVDGTAGG LDEPGVASDG
   421  LPSSEPGPCS FQQLDESPAV PLSHRPPALA DPASYQPAVT APEPDASPRL AVDFALPKEL
   481  PLISSHVDLS GDPEETVAPA QVALSVTEFG LIGIGDVNPF LAAHPTCPAP GLHSEPLSHC
   541  NVMTC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIER2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 34 nTPM
  • spleen: 31 nTPM
  • testis: 29 nTPM
  • lung: 27 nTPM
  • skin: 24 nTPM
  • adipose tissue: 24 nTPM

Single-cell type

  • syncytiotrophoblasts: 37 nCPM
  • undifferentiated spermatogonia: 33 nCPM
  • vascular endothelial cells: 33 nCPM
  • late spermatids: 32 nCPM
  • differentiating spermatogonia: 30 nCPM
  • cytotrophoblasts: 29 nCPM

Immune cell

  • myeloid DC: 4.5 nTPM
  • classical monocyte: 4 nTPM
  • basophil: 3.9 nTPM
  • non-classical monocyte: 3.7 nTPM
  • intermediate monocyte: 3.5 nTPM
  • eosinophil: 2.7 nTPM

Brain region

  • amygdala: 23 nTPM
  • medulla oblongata: 23 nTPM
  • midbrain: 21 nTPM
  • cerebral cortex: 21 nTPM
  • pons: 20 nTPM
  • thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.9
gnomAD missense Z
0.56
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MIER2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIER2 as an antibody target. Whether an autoantibody or antibody against MIER2 could matter depends on whether native MIER2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIER2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIER2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MIER2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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