Seroatlas · Human Serome Atlas

TERF2

Telomeric repeat-binding factor 2

Also known as: TERF2_HUMAN, TRBF2, TRF2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15554
Gene
TERF2
Ensembl
ENSG00000132604
Chromosome
16
Canonical length
542 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>Q15554|TERF2
     1  MAAGAGTAGP ASGPGVVRDP AASQPRKRPG REGGEGARRS DTMAGGGGSS DGSGRAAGRR
    61  ASRSSGRARR GRHEPGLGGP AERGAGEARL EEAVNRWVLK FYFHEALRAF RGSRYGDFRQ
   121  IRDIMQALLV RPLGKEHTVS RLLRVMQCLS RIEEGENLDC SFDMEAELTP LESAINVLEM
   181  IKTEFTLTEA VVESSRKLVK EAAVIICIKN KEFEKASKIL KKHMSKDPTT QKLRNDLLNI
   241  IREKNLAHPV IQNFSYETFQ QKMLRFLESH LDDAEPYLLT MAKKALKSES AASSTGKEDK
   301  QPAPGPVEKP PREPARQLRN PPTTIGMMTL KAAFKTLSGA QDSEAAFAKL DQKDLVLPTQ
   361  ALPASPALKN KRPRKDENES SAPADGEGGS ELQPKNKRMT ISRLVLEEDS QSTEPSAGLN
   421  SSQEAASAPP SKPTVLNQPL PGEKNPKVPK GKWNSSNGVE EKETWVEEDE LFQVQAAPDE
   481  DSTTNITKKQ KWTVEESEWV KAGVQKYGEG NWAAISKNYP FVNRTAVMIK DRWRTMKRLG
   541  MN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TERF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 42 nTPM
  • lymph node: 33 nTPM
  • skeletal muscle: 30 nTPM
  • cerebellum: 27 nTPM
  • cerebral cortex: 25 nTPM
  • tongue: 21 nTPM

Single-cell type

  • early spermatids: 68 nCPM
  • b-cells: 48 nCPM
  • myonuclei: 48 nCPM
  • thymocytes: 42 nCPM
  • neutrophil progenitors: 40 nCPM
  • hematopoietic stem cells: 39 nCPM

Immune cell

  • basophil: 13 nTPM
  • memory B-cell: 13 nTPM
  • naive B-cell: 8.3 nTPM
  • naive CD4 T-cell: 6.2 nTPM
  • naive CD8 T-cell: 6.1 nTPM
  • gdT-cell: 5.8 nTPM

Brain region

  • cerebral cortex: 65 nTPM
  • cerebellum: 56 nTPM
  • white matter: 56 nTPM
  • hypothalamus: 52 nTPM
  • midbrain: 51 nTPM
  • basal ganglia: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.99
gnomAD missense Z
2.07
DepMap mean gene effect
-0.97
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TERF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TERF2 as an antibody target. Whether an autoantibody or antibody against TERF2 could matter depends on whether native TERF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TERF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TERF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TERF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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