Seroatlas · Human Serome Atlas

MIDEAS

Mitotic deacetylase-associated SANT domain protein

Also known as: C14orf117, C14orf43, ELMSAN1, LSR68, MDEAS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PJG2
Gene
MIDEAS
Ensembl
ENSG00000156030
Chromosome
14
Canonical length
1045 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1045 residues, UniProt reviewed canonical sequence.

>Q6PJG2|MIDEAS
     1  MNLQAQPKAQ NKRKRCLFGG QEPAPKEQPP PLQPPQQSIR VKEEQYLGHE GPGGAVSTSQ
    61  PVELPPPSSL ALLNSVVYGP ERTSAAMLSQ QVASVKWPNS VMAPGRGPER GGGGGVSDSS
   121  WQQQPGQPPP HSTWNCHSLS LYSATKGSPH PGVGVPTYYN HPEALKREKA GGPQLDRYVR
   181  PMMPQKVQLE VGRPQAPLNS FHAAKKPPNQ SLPLQPFQLA FGHQVNRQVF RQGPPPPNPV
   241  AAFPPQKQQQ QQQPQQQQQQ QQAALPQMPL FENFYSMPQQ PSQQPQDFGL QPAGPLGQSH
   301  LAHHSMAPYP FPPNPDMNPE LRKALLQDSA PQPALPQVQI PFPRRSRRLS KEGILPPSAL
   361  DGAGTQPGQE ATGNLFLHHW PLQQPPPGSL GQPHPEALGF PLELRESQLL PDGERLAPNG
   421  REREAPAMGS EEGMRAVSTG DCGQVLRGGV IQSTRRRRRA SQEANLLTLA QKAVELASLQ
   481  NAKDGSGSEE KRKSVLASTT KCGVEFSEPS LATKRAREDS GMVPLIIPVS VPVRTVDPTE
   541  AAQAGGLDED GKGPEQNPAE HKPSVIVTRR RSTRIPGTDA QAQAEDMNVK LEGEPSVRKP
   601  KQRPRPEPLI IPTKAGTFIA PPVYSNITPY QSHLRSPVRL ADHPSERSFE LPPYTPPPIL
   661  SPVREGSGLY FNAIISTSTI PAPPPITPKS AHRTLLRTNS AEVTPPVLSV MGEATPVSIE
   721  PRINVGSRFQ AEIPLMRDRA LAAADPHKAD LVWQPWEDLE SSREKQRQVE DLLTAACSSI
   781  FPGAGTNQEL ALHCLHESRG DILETLNKLL LKKPLRPHNH PLATYHYTGS DQWKMAERKL
   841  FNKGIAIYKK DFFLVQKLIQ TKTVAQCVEF YYTYKKQVKI GRNGTLTFGD VDTSDEKSAQ
   901  EEVEVDIKTS QKFPRVPLPR RESPSEERLE PKREVKEPRK EGEEEVPEIQ EKEEQEEGRE
   961  RSRRAAAVKA TQTLQANESA SDILILRSHE SNAPGSAGGQ ASEKPREGTG KSRRALPFSE
  1021  KKKKTETFSK TQNQENTFPC KKCGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIDEAS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 13 nTPM
  • spleen: 13 nTPM
  • skin: 12 nTPM
  • skeletal muscle: 9.5 nTPM
  • parathyroid gland: 9.3 nTPM
  • appendix: 8.7 nTPM

Single-cell type

  • epicardial cells: 582 nCPM
  • endometrial glandular cells: 252 nCPM
  • endometrial luminal cells: 193 nCPM
  • smooth muscle cells: 154 nCPM
  • epididymal basal cells: 153 nCPM
  • endometrial ciliated cells: 149 nCPM

Immune cell

  • plasmacytoid DC: 1.2 nTPM
  • neutrophil: 0.9 nTPM
  • naive B-cell: 0.7 nTPM
  • basophil: 0.6 nTPM
  • myeloid DC: 0.6 nTPM
  • classical monocyte: 0.5 nTPM

Brain region

  • white matter: 41 nTPM
  • thalamus: 38 nTPM
  • cerebellum: 37 nTPM
  • cerebral cortex: 37 nTPM
  • medulla oblongata: 37 nTPM
  • amygdala: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MIDEAS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIDEAS as an antibody target. Whether an autoantibody or antibody against MIDEAS could matter depends on whether native MIDEAS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIDEAS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIDEAS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MIDEAS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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