Seroatlas · Human Serome Atlas

TERF1

Telomeric repeat-binding factor 1

Also known as: PIN2, TERF1_HUMAN, TRBF1, TRF, TRF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P54274
Gene
TERF1
Ensembl
ENSG00000147601
Chromosome
8
Canonical length
439 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli fibrillar center,Nuclear bodies
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Multiple transcripts of this gene are alternatively spliced products. [provided by RefSeq, Aug 2022]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>P54274|TERF1
     1  MAEDVSSAAP SPRGCADGRD ADPTEEQMAE TERNDEEQFE CQELLECQVQ VGAPEEEEEE
    61  EEDAGLVAEA EAVAAGWMLD FLCLSLCRAF RDGRSEDFRR TRNSAEAIIH GLSSLTACQL
   121  RTIYICQFLT RIAAGKTLDA QFENDERITP LESALMIWGS IEKEHDKLHE EIQNLIKIQA
   181  IAVCMENGNF KEAEEVFERI FGDPNSHMPF KSKLLMIISQ KDTFHSFFQH FSYNHMMEKI
   241  KSYVNYVLSE KSSTFLMKAA AKVVESKRTR TITSQDKPSG NDVEMETEAN LDTRKSVSDK
   301  QSAVTESSEG TVSLLRSHKN LFLSKLQHGT QQQDLNKKER RVGTPQSTKK KKESRRATES
   361  RIPVSKSQPV TPEKHRARKR QAWLWEEDKN LRSGVRKYGE GNWSKILLHY KFNNRTSVML
   421  KDRWRTMKKL KLISSDSED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TERF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 15 nTPM
  • cerebral cortex: 15 nTPM
  • kidney: 13 nTPM
  • cerebellum: 13 nTPM
  • prostate: 12 nTPM
  • parathyroid gland: 12 nTPM

Single-cell type

  • early primary spermatocytes: 181 nCPM
  • differentiating spermatogonia: 139 nCPM
  • oocytes: 134 nCPM
  • ovarian stromal cells: 96 nCPM
  • müller glia: 87 nCPM
  • schwann cells: 86 nCPM

Immune cell

  • naive CD8 T-cell: 13 nTPM
  • naive CD4 T-cell: 12 nTPM
  • memory B-cell: 12 nTPM
  • basophil: 12 nTPM
  • memory CD8 T-cell: 11 nTPM
  • plasmacytoid DC: 11 nTPM

Brain region

  • cerebellum: 20 nTPM
  • cerebral cortex: 17 nTPM
  • white matter: 16 nTPM
  • spinal cord: 14 nTPM
  • basal ganglia: 14 nTPM
  • hippocampal formation: 13 nTPM

ReferencesPubMed · IEDB

Publications for TERF1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.91
gnomAD missense Z
0.37

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TERF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TERF1 as an antibody target. Whether an autoantibody or antibody against TERF1 could matter depends on whether native TERF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TERF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TERF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TERF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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