Seroatlas · Human Serome Atlas

BDP1

Transcription factor TFIIIB component B'' homolog

Also known as: BDP1_HUMAN, HSA238520, KIAA1241, KIAA1689, TAF3B1, TFC5, TFIIIB150, TFIIIB90, TFNR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6H8Y1
Gene: BDP1
Ensembl: ENSG00000145734
Chromosome: 5
Canonical length: 2624 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

2624 residues, UniProt reviewed canonical sequence.

>A6H8Y1|BDP1
     1  MFRRARLSVK PNVRPGVGAR GSTASNPQRG RESPRPPDPA TDSASKPAEP TDVPTVDFGG
    61  AEPQEKAPRS STEKTGGDND VEESSRSSST VSQRRKRISS TSSLVKSSVS VPSESHPLST
   121  INQEAPQPTA TSTKEKQPCS DRYRIYKAQK LREMLKEELR KEKKQWKNKY AINESQRPPD
   181  RSKMTMRDFI YYLPDNNPMT SSLEQEKKTE KPSTPVQTRE QEGKSTPNAE DNEMEEETDD
   241  GPLLVPRVKV AEDGSIILDE ESLTVEVLRT KGPCVVEEND PIFERGSTTT YSSFRKNYYS
   301  KPWSNKETDM FFLAISMVGT DFSMIGQLFP HRARIEIKNK FKREEKTNGW RIDKAFQEKR
   361  PFDFDFFAHL LQKVLAEEEK RKQKSVKNHS LKEKKSTKPR KNVKVKKVAC EGVNNDPDES
   421  MSSRISDTER SQKDAQTVEE ESLTLSREDA EQVALEVDLN QKKRRRKKQD GANELGVNNL
   481  LENATVQAGP SKGEKHKNKC QAIRPELKEG ECSKEQMLSC TQNIDGIVGF ASTEKVEKRT
   541  DPILSLSNQQ DATSVATESS ESSTSDLPSF EVGIRALCEV NNAEGSCIEE RNVDLKNNSL
   601  EIDQTENVKP MLRGRFQRPK PNLSRAGKKS VLSQGKTESE SKNSHSKTSV EKNHVEKDKM
   661  NTLDILRMET TERENPEAET VSVLGEKNCL QEGSQLKALR PVQVRGRLQK PKPNAGKAAE
   721  RKEILISQEE IGANVEKNEN ESCADRDTPQ HMEDQSRKDF EEEDVILQPE KNDSFQNVQP
   781  DEPKVLNECL SVQENNKANK LNQVPILRTR FQKPKPNIGR GTGRREISSK EEVLEKILVS
   841  GEMAAALRET VRLDTSPKEM VPAEINTKEM QSDLKETGRR AISPREKILD VIDDTIEMET
   901  GLKAMGREIC LREKTPEVID ATEEIDKDLE EAGRREISPQ KNGPEEVKPL GEVETDLKAT
   961  GNESSPREKT PEVTDATEEI DKNLEETGRR KISPRENGPE EVKPVDEMET DLNATGRESS
  1021  PREKTPEVID ATEEIDLEET EREVSPQENG LEEVKPLGEM ETDLKATGRD SFPRGKTPEV
  1081  IDAIEEIEID LEETEREISP QENGLEEVKP LGEMQTDLKA TGREISPREK TPEVIDATEE
  1141  IDKDLEETGR REISPEENGP EEVKPVDEME TDLKTTGREG SSREKTREVI DAAEVIETDL
  1201  EETEREISPQ ENGPEEVKPV GKMETDLKEI REEISQREKV LAEFSAIREK EIDLKETGKR
  1261  DIPIMEKVSG KMAVVEEMEA DLKETGKENF RERGSEEICV TEEKVAELKQ TGKTDISPRE
  1321  NELEETSTSR QTDTHLMQSG SNDFSAVPSL DIQNISSEVL SMMHTPVEEK RNSEKEVSSH
  1381  FSHFKISSQT HESDKTEVQG IQSPDVPEQF SDINLSKSLP QEQKPLEIKP APFVRSRFKR
  1441  PKPNLARAAL KRETTESEKY IYEKKSETKK METIVMQENN EQTDTLPSQH DEASLMISRE
  1501  KDTLGHRNEE AVILPCTQTE RNLSPSNSCE PKEESQSAPV QKNDSVVSVG TNNVNTFQQE
  1561  MKESVIQTAR QVRGRLQRPR PNIRKTGQRQ IVDKGEAKGI IKEGRTILPK DETEKKVLTV
  1621  SNSQIETEIE VPSSAVPEHR MYENQSQVVL VENLHVNKTN ETIRHENKPY VPSSAQMTRR
  1681  KFQKAKPNLG RAHSKKEEPV LEKVTTDQSK EGKPEDHLLQ KGASNTQLLL KEKAELLTSL
  1741  EVSARKDCVG SKESALAKID AELEEVGPSR RVGEETVGDN SPSSVVEEQY LNKLTSCPQP
  1801  LNETSYSKIA LDGKTTISST SEYERNRGER RSHKKFKPNV TRGRGSKRVR GKTSKKEPRA
  1861  SKAMLVTLRA SQEEDDDADD FESDYEEESY HLAPEEVNKA PVFVPVGLRS PEPVSAQIEE
  1921  TMEELEITVN VPDVGCIAVV EHELPNTDVT TEEMKQEENL SVPFEMTTSE HIQDEPGTND
  1981  GSTEAAITLL TMGDLVLQSE ISSEQGDVGV CIIPHVHSKD KSHIPSSLDN VNHKIVHECQ
  2041  ELSSPVITTS PASFEENKIV LEEQSSREEI SLMEKVKENA TPTRNTISKV TSNLRIRSRL
  2101  AKPKPNLEKT LGTNRLDDYQ EVSSLCVTKG AEMETQRETE KNASKATELE NKNLGPVTTA
  2161  ENKDQSKLAC VHGIKGTSIS SEVNLTERNE NQEESSQEVH MLSVAPVASS ETGPCTLGLD
  2221  RGLGENSVEE PQIKDSKGDS VLTLPVPEYT PTSIPEVQQE NIINPQDLTV NLVANVPQDG
  2281  EDEQAFILTL VEIPANAVEE FTDATAQFMP NPLLPAPILV KSVNTEERGD MSICLPATSV
  2341  GQDAMGLSIS GRDNSKKPPD NLDLVSRKRF QCRLDKNDHI PPAKKRSLTL RDDCQEYTTE
  2401  VHSKELTNVF EETGESHKGQ DIFLTSGSTL TTPEPQRQQV EAAFQSRGSR SPDACMDKNV
  2461  PQLPQDEMIV SDKEERTDAA PKSQQMDSRT SSSKASLSRP GRRPLGFLSL ICSKNSLESD
  2521  EPMQVHSKKR LKPLIPGLRK KLKRSNPFNE SQEKNRESSD LLPSPSVITT QSENISSSAT
  2581  QVSCDQPLLK EGYKSAQKRA PQGEATTVSE YFFNDIFIEV DETE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BDP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 5.2 nTPM

Expression across tissuesHPA

Tissue

retina: 5.2 nTPM
pancreas: 3.7 nTPM
tongue: 3.3 nTPM
breast: 3.2 nTPM
thyroid gland: 2.6 nTPM
adrenal gland: 2.5 nTPM

Single-cell type

renal collecting duct intercalated cells: 220 nCPM
distal convoluted tubule cells: 197 nCPM
proximal tubule cells: 197 nCPM
renal connecting tubule cells: 184 nCPM
brain excitatory neurons: 157 nCPM
brain inhibitory neurons: 157 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2.1 nTPM
cerebellum: 2 nTPM
white matter: 1.9 nTPM
hypothalamus: 1.7 nTPM
medulla oblongata: 1.7 nTPM
amygdala: 1.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BDP1.

Disease | AllUniProt

Conditions BDP1 is implicated in, by any mechanism.

Deafness, autosomal recessive, 112 (DFNB112) MIM:618257

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 667 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hearing loss, autosomal recessive 112
Deafness

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.9
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

RNA polymerase III preinitiation complex assembly

Molecular functions

TFIIIC-class transcription factor complex binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

SANT/Myb domain
Homedomain-like superfamily
Transcription factor TFIIIB component B'', Myb domain
Myb DNA-binding like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BDP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BDP1 as an antibody target. Whether an autoantibody or antibody against BDP1 could matter depends on whether native BDP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BDP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BDP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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