Seroatlas · Human Serome Atlas

MYB

Transcriptional activator Myb

Also known as: c-myb, MYB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P10242
Gene
MYB
Ensembl
ENSG00000118513
Chromosome
6
Canonical length
640 aa
Protein class
Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

640 residues, UniProt reviewed canonical sequence.

>P10242|MYB
     1  MARRPRHSIY SSDEDDEDFE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK LKKLVEQNGT
    61  DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED QRVIELVQKY GPKRWSVIAK
   121  HLKGRIGKQC RERWHNHLNP EVKKTSWTEE EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA
   181  IKNHWNSTMR RKVEQEGYLQ ESSKASQPAV ATSFQKNSHL MGFAQAPPTA QLPATGQPTV
   241  NNDYSYYHIS EAQNVSSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL
   301  LLMSTENELK GQQVLPTQNH TCSYPGWHST TIADHTRPHG DSAPVSCLGE HHSTPSLPAD
   361  PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID SFLNTSSNHE NSDLEMPSLT
   421  STPLIGHKLT VTTPFHRDQT VKTQKENTVF RTPAIKRSIL ESSPRTPTPF KHALAAQEIK
   481  YGPLKMLPQT PSHLVEDLQD VIKQESDESG IVAEFQENGP PLLKKIKQEV ESPTDKSGNF
   541  FCSHHWEGDS LNTQLFTQTS PVADAPNILT SSVLMAPASE DEDNVLKAFT VPKNRSLASP
   601  LQPCSSTWEP ASCGKMEEQM TSSSQARKYV NAFSARTLVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 62 nTPM
  • bone marrow: 33 nTPM
  • rectum: 25 nTPM
  • colon: 24 nTPM
  • breast: 19 nTPM
  • duodenum: 10 nTPM

Single-cell type

  • megakaryocyte-erythroid progenitors: 315 nCPM
  • hematopoietic stem cells: 281 nCPM
  • neutrophil progenitors: 215 nCPM
  • erythrocyte progenitors: 175 nCPM
  • respiratory deuterosomal cells: 158 nCPM
  • respiratory ciliated cells: 125 nCPM

Immune cell

  • eosinophil: 5.3 nTPM
  • basophil: 4.5 nTPM
  • plasmacytoid DC: 1.5 nTPM
  • classical monocyte: 0.6 nTPM
  • T-reg: 0.4 nTPM
  • MAIT T-cell: 0.2 nTPM

Brain region

  • amygdala: 3.6 nTPM
  • basal ganglia: 3.6 nTPM
  • medulla oblongata: 2.3 nTPM
  • midbrain: 2.3 nTPM
  • choroid plexus: 1.1 nTPM
  • cerebral cortex: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.82
gnomAD missense Z
2.51
DepMap mean gene effect
-0.34
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYB as an antibody target. Whether an autoantibody or antibody against MYB could matter depends on whether native MYB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MYB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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