MYPOP

Protein identityUniProt · HPA

UniProt accession

Q86VE0

Gene

MYPOP

Ensembl

ENSG00000176182

Chromosome

19

Canonical length

399 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm

Quaternary structure

Homodimer

OverviewNCBI Gene

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>Q86VE0|MYPOP
     1  MASAAAGEAE ETTRLRKPRF SFEENQILIR EVRAHYPQLY GAQSRRVSVA ERRRVWDGIA
    61  AKINGITSWK RTGQEVQKRW NDFKRRTKEK LARVPHSTQG AGPAAEDAFS AEEETIFAIL
   121  GPGVAAPGAG AGAEEPPAAP SSQPPPPSAC PQRYVLSEDR REDRRADTSA HSKAGSSSPE
   181  PWARPSCTPQ EGGCPRPKER ESPPPSALQP VQLPRLALSP PPPAPPLPPP PPLAQVAPSP
   241  PSPPPPPRPP PTLSASDPSL DFLRAQQETA NAIRELAGTL RQGLAKLSEA LSALLPLLPG
   301  TPVDSLPPPL PPPPPPPPPP RPVLPPPAPK VEITPEPVSV VAAVVDGAVV AARGVIIAPR
   361  SEEGAPRPPP APLPPHDSPP HKRRKGFPTR KRRGRWKSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYPOP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.62

Highest tissue expression

29 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.6

gnomAD pLI

0.67

gnomAD missense Z

0.98

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• DNA-binding transcription repressor activity, RNA polymerase II-specific
• identical protein binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• SANT/Myb domain
• Myb/SANT-like DNA-binding domain 5
• Myb/SANT-like DNA-binding domain
• Myb-related transcriptional repressor

KeywordsUniProt

• DNA-binding
• Nucleus
• Repressor
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of MYPOP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PFN1