Seroatlas · Human Serome Atlas

TERB1

Telomere repeats-binding bouquet formation protein 1

Also known as: CCDC79, FLJ35894, TERB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NA31
Gene
TERB1
Ensembl
ENSG00000249961
Chromosome
16
Canonical length
727 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cell Junctions,Cytosol

OverviewNCBI Gene

Predicted to be involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Predicted to act upstream of or within double-strand break repair involved in meiotic recombination. Predicted to be located in nuclear inner membrane and shelterin complex. Implicated in spermatogenic failure 60. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

727 residues, UniProt reviewed canonical sequence.

>Q8NA31|TERB1
     1  MESEDTKKTQ EMKTDLNLLL ECLKYQMDNA FSQKEALVTI HSICQQNSNA SVYFREIGGL
    61  MFVKNLAKSS EHSMVKEAAL YTLGAIAEKN VYCQQTLCTS ELFEDLTWFL SNDSNINLKR
   121  MSVYVILVLV SNNRTGQTLV RETGCITVLS RLFRTVISKH ELDLSDKNVF QSYQLWSSVC
   181  STLCVCVNNP QNDENQMFCC SLFPHANEWL KNCTTPEIIR PICSFIGLTL ANNTYVQKYF
   241  VSVGGLDVLS QVLMQLESDS HETLSSAKLA VVVTKTVDAC IADNPTFGIV LSKYHIVSKL
   301  LALLLHESLD SGEKFSIMLT LGHCTEDCEE NQYDLFKNNG LPLMIQALTE SQNEELNKAA
   361  TFVLHNCKKI TEKLSLSLGE YPFDENETQQ LKDISVKENN LEEHWRKAKE ILHRIEQLER
   421  EGNEEEIQRE NYQDNISSMN ISIQNTWKHL HADRIGRGSK AEDEDKSHSR QLQSYKSHGV
   481  MSKACTNDDQ MKTPLKSANP VHACYRESEQ NKTLYKAKSS CNQNLHEETT FEKNFVSQSS
   541  DHVFKHPVHI AKNIKQQLPV TDPFTLCSDI INKEVVSFLA TPSCSEMLTY RCSGCIAVEK
   601  SLNSRNFSKL LHSCPYQCDR HKVIVEAEDR YKSELRKSLI CNKKILLTPR RRQRLSNEST
   661  TPGGIKKRRI RKNFTEEEVN YLFNGVKKMG NHWNSILWSF PFQQGRKAVD LAHKYHKLTK
   721  HPTCAAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TERB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • testis: 12 nTPM
  • bone marrow: 1.4 nTPM
  • skin: 0.6 nTPM
  • retina: 0.4 nTPM
  • adrenal gland: 0.3 nTPM
  • cerebral cortex: 0.3 nTPM

Single-cell type

  • early primary spermatocytes: 370 nCPM
  • differentiating spermatogonia: 55 nCPM
  • late primary spermatocytes: 53 nCPM
  • undifferentiated spermatogonia: 27 nCPM
  • early spermatids: 22 nCPM
  • late spermatids: 15 nCPM

Immune cell

  • basophil: 1.8 nTPM
  • neutrophil: 0.7 nTPM
  • NK-cell: 0.4 nTPM
  • naive B-cell: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • memory B-cell: 0.2 nTPM

Brain region

  • choroid plexus: 7.9 nTPM
  • cerebellum: 7.6 nTPM
  • medulla oblongata: 7.6 nTPM
  • white matter: 7.6 nTPM
  • cerebral cortex: 6.5 nTPM
  • pons: 6.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TERB1.

Disease | AllUniProt

Conditions TERB1 is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 20 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TERB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TERB1 as an antibody target. Whether an autoantibody or antibody against TERB1 could matter depends on whether native TERB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TERB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TERB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TERB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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