Seroatlas · Human Serome Atlas

GON4L

GON-4-like protein

Also known as: FLJ20203, GON-4, GON4, GON4L_HUMAN, YARP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3T8J9
Gene
GON4L
Ensembl
ENSG00000116580
Chromosome
1
Canonical length
2241 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within B cell differentiation. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2241 residues, UniProt reviewed canonical sequence.

>Q3T8J9|GON4L
     1  MLPCKKRRTT VTESLQHKGN QEENNVDLES AVKPESDQVK DLSSVSLSWD PSHGRVAGFE
    61  VQSLQDAGNQ LGMEDTSLSS GMLTQNTNVP ILEGVDVAIS QGITLPSLES FHPLNIHIGK
   121  GKLHATGSKR GKKMTLRPGP VTQEDRCDHL TLKEPFSGEP SEEVKEEGGK PQMNSEGEIP
   181  SLPSGSQSAK PVSQPRKSTQ PDVCASPQEK PLRTLFHQPE EEIEDGGLFI PMEEQDNEES
   241  EKRRKKKKGT KRKRDGRGQE GTLAYDLKLD DMLDRTLEDG AKQHNLTAVN VRNILHEVIT
   301  NEHVVAMMKA AISETEDMPM FEPKMTRSKL KEVVEKGVVI PTWNISPIKK ANEIKPPQFV
   361  DIHLEEDDSS DEEYQPDDEE EDETAEESLL ESDVESTASS PRGAKKSRLR QSSEMTETDE
   421  ESGILSEAEK VTTPAIRHIS AEVVPMGPPP PPKPKQTRDS TFMEKLHAVD EELASSPVCM
   481  DSFQPMDDSL IAFRTRSKMP LKDVPLGQLE AELQAPDITP DMYDPNTADD EDWKMWLGGL
   541  MNDDVGNEDE ADDDDDPEYN FLEDLDEPDT EDFRTDRAVR ITKKEVNELM EELFETFQDE
   601  MGFSNMEDDG PEEEECVAEP RPNFNTPQAL RFEEPLANLL NEQHRTVKEL FEQLKMKKSS
   661  AKQLQEVEKV KPQSEKVHQT LILDPAQRKR LQQQMQQHVQ LLTQIHLLAT CNPNLNPEAT
   721  TTRIFLKELG TFAQSSIALH HQYNPKFQTL FQPCNLMGAM QLIEDFSTHV SIDCSPHKTV
   781  KKTANEFPCL PKQVAWILAT SKVFMYPELL PVCSLKAKNP QDKIVFTKAE DNLLALGLKH
   841  FEGTEFPNPL ISKYLLTCKT AHQLTVRIKN LNMNRAPDNI IKFYKKTKQL PVLGKCCEEI
   901  QPHQWKPPIE REEHRLPFWL KASLPSIQEE LRHMADGARE VGNMTGTTEI NSDRSLEKDN
   961  LELGSESRYP LLLPKGVVLK LKPVATRFPR KAWRQKRSSV LKPLLIQPSP SLQPSFNPGK
  1021  TPARSTHSEA PPSKMVLRIP HPIQPATVLQ TVPGVPPLGV SGGESFESPA ALPAVPPEAR
  1081  TSFPLSESQT LLSSAPVPKV MLPSLAPSKF RKPYVRRRPS KRRGVKASPC MKPAPVIHHP
  1141  ASVIFTVPAT TVKIVSLGGG CNMIQPVNAA VAQSPQTIPI TTLLVNPTSF PCPLNQSLVA
  1201  SSVSPLIVSG NSVNLPIPST PEDKAHVNVD IACAVADGEN AFQGLEPKLE PQELSPLSAT
  1261  VFPKVEHSPG PPLADAECQE GLSENSACRW TVVKTEEGRQ ALEPLPQGIQ ESLNNPTPGD
  1321  LEEIVKMEPE EAREEISGSP ERDICDDIKV EHAVELDTGA PSEELSSAGE VTKQTVLQKE
  1381  EERSQPTKTP SSSQEPPDEG TSGTDVNKGS SKNALSSMDP EVRLSSPPGK PEDSSSVDGQ
  1441  SVGTPVGPET GGEKNGPEEE EEEDFDDLTQ DEEDEMSSAS EESVLSVPEL QETMEKLTWL
  1501  ASERRMSQEG ESEEENSQEE NSEPEEEEEE EAEGMESLQK EDEMTDEAVG DSAEKPPTFA
  1561  SPETAPEVET SRTPPGESIK AAGKGRNNHR ARNKRGSRAR ASKDTSKLLL LYDEDILERD
  1621  PLREQKDLAF AQAYLTRVRE ALQHIPGKYE DFLQVIYEFE SSTQRRTAVD LYKSLQILLQ
  1681  DWPQLLKDFA AFLLPEQALA CGLFEEQQAF EKSRKFLRQL EICFAENPSH HQKIIKVLQG
  1741  CADCLPQEIT ELKTQMWQLL KGHDHLQDEF SIFFDHLRPA ASRMGDFEEI NWTEEKEYEF
  1801  DGFEEVALPD VEEEEEPPKI PTASKNKRKK EIGVQNHDKE TEWPDGAKDC ACSCHEGGPD
  1861  SKLKKSKRRS CSHCSSKVCD SKSYKSKEPH ELVGSSPHRE ASPMPGAKEA GQGKDMMEEE
  1921  APEERESTEA TQSRTVRTTR KGEMPVSAGL AVGSTLPSPR EVTVTERLLL DGPPPHSPET
  1981  PQFPPTTGAV LYTVKRNQVG PEVRSCPKAS PRLQKEREGQ KAVSESEALM LVWDASETEK
  2041  LPGTVEPPAS FLSPVSSKTR DAGRRHVSGK PDTQERWLPS SRARVKTRDR TCPVHESPSG
  2101  IDTSETSPKA PRGGLAKDSG TQAKGPEGEQ QPKAAEATVC ANNSKVSSTG EKVVLWTREA
  2161  DRVILTMCQE QGAQPQTFNI ISQQLGNKTP AEVSHRFREL MQLFHTACEA SSEDEDDATS
  2221  TSNADQLSDH GDLLSEEELD E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GON4L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 14 nTPM
  • retina: 13 nTPM
  • spleen: 12 nTPM
  • skeletal muscle: 12 nTPM
  • lymph node: 12 nTPM
  • tonsil: 11 nTPM

Single-cell type

  • ependymal cells: 173 nCPM
  • rod photoreceptor cells: 156 nCPM
  • proximal tubule cells: 150 nCPM
  • pituicytes/fscs: 135 nCPM
  • sertoli cells: 131 nCPM
  • retinal ganglion cells: 128 nCPM

Immune cell

  • NK-cell: 4.1 nTPM
  • neutrophil: 3.3 nTPM
  • gdT-cell: 2.5 nTPM
  • basophil: 2.4 nTPM
  • naive B-cell: 2.4 nTPM
  • myeloid DC: 2.2 nTPM

Brain region

  • cerebellum: 29 nTPM
  • choroid plexus: 26 nTPM
  • midbrain: 25 nTPM
  • white matter: 24 nTPM
  • cerebral cortex: 24 nTPM
  • thalamus: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GON4L.

Disease | AllUniProt

Conditions GON4L is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 88 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Li-Takada-Miyake syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.95
gnomAD missense Z
1.65
DepMap mean gene effect
-0.5
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GON4L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GON4L as an antibody target. Whether an autoantibody or antibody against GON4L could matter depends on whether native GON4L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GON4L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GON4L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GON4L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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