Seroatlas · Human Serome Atlas

SRC

Proto-oncogene tyrosine-protein kinase Src

Also known as: ASV, c-src, SRC_HUMAN, SRC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P12931
Gene
SRC
Ensembl
ENSG00000197122
Chromosome
20
Canonical length
536 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Vesicles,Plasma membrane,Cell Junctions

OverviewNCBI Gene

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>P12931|SRC
     1  MGSNKSKPKD ASQRRRSLEP AENVHGAGGG AFPASQTPSK PASADGHRGP SAAFAPAAAE
    61  PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTEGD
   121  WWLAHSLSTG QTGYIPSNYV APSDSIQAEE WYFGKITRRE SERLLLNAEN PRGTFLVRES
   181  ETTKGAYCLS VSDFDNAKGL NVKHYKIRKL DSGGFYITSR TQFNSLQQLV AYYSKHADGL
   241  CHRLTTVCPT SKPQTQGLAK DAWEIPRESL RLEVKLGQGC FGEVWMGTWN GTTRVAIKTL
   301  KPGTMSPEAF LQEAQVMKKL RHEKLVQLYA VVSEEPIYIV TEYMSKGSLL DFLKGETGKY
   361  LRLPQLVDMA AQIASGMAYV ERMNYVHRDL RAANILVGEN LVCKVADFGL ARLIEDNEYT
   421  ARQGAKFPIK WTAPEAALYG RFTIKSDVWS FGILLTELTT KGRVPYPGMV NREVLDQVER
   481  GYRMPCPPEC PESLHDLMCQ CWRKEPEERP TFEYLQAFLE DYFTSTEPQY QPGENL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 20 nTPM
  • duodenum: 19 nTPM
  • small intestine: 18 nTPM
  • pancreas: 15 nTPM
  • seminal vesicle: 14 nTPM
  • urinary bladder: 14 nTPM

Single-cell type

  • megakaryocytes: 173 nCPM
  • urothelial cells: 122 nCPM
  • platelets: 120 nCPM
  • foveolar cells: 97 nCPM
  • esophageal apical cells: 83 nCPM
  • sertoli cells: 70 nCPM

Immune cell

  • intermediate monocyte: 1.9 nTPM
  • non-classical monocyte: 1.7 nTPM
  • classical monocyte: 1.2 nTPM
  • total PBMC: 1.1 nTPM
  • plasmacytoid DC: 1 nTPM
  • myeloid DC: 0.5 nTPM

Brain region

  • hippocampal formation: 33 nTPM
  • cerebral cortex: 30 nTPM
  • amygdala: 30 nTPM
  • basal ganglia: 28 nTPM
  • hypothalamus: 27 nTPM
  • thalamus: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SRC.

Disease | AllUniProt

Conditions SRC is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 116 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
1
gnomAD missense Z
3.87
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRC as an antibody target. Whether an autoantibody or antibody against SRC could matter depends on whether native SRC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRC is annotated at the cell surface, where native SRC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SRC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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