Seroatlas · Human Serome Atlas

ARRB2

Beta-arrestin-2

Also known as: ARR2, ARRB2_HUMAN, BARR2, DKFZp686L0365

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P32121
Gene: ARRB2
Ensembl: ENSG00000141480
Chromosome: 17
Canonical length: 409 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

409 residues, UniProt reviewed canonical sequence.

>P32121|ARRB2
     1  MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC
    61  AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI
   121  PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG
   181  PQPSAETTRH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA
   241  DICLFSTAQY KCPVAQLEQD DQVSPSSTFC KVYTITPLLS DNREKRGLAL DGKLKHEDTN
   301  LASSTIVKEG ANKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPH DHIPLPRPQS
   361  AAPETDVPVD TNLIEFDTNY ATDDDIVFED FARLRLKGMK DDDYDDQLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARRB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 249 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 249 nTPM
spleen: 158 nTPM
appendix: 104 nTPM
lung: 89 nTPM
cerebellum: 64 nTPM
hippocampal formation: 63 nTPM

Single-cell type

neutrophils: 934 nCPM
hofbauer cells: 396 nCPM
monocytes: 334 nCPM
kupffer cells: 251 nCPM
neutrophil progenitors: 241 nCPM
macrophages: 199 nCPM

Immune cell

eosinophil: 270 nTPM
neutrophil: 252 nTPM
non-classical monocyte: 169 nTPM
intermediate monocyte: 151 nTPM
classical monocyte: 146 nTPM
basophil: 117 nTPM

Brain region

hypothalamus: 86 nTPM
white matter: 86 nTPM
hippocampal formation: 79 nTPM
medulla oblongata: 75 nTPM
cerebral cortex: 73 nTPM
pons: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.51
gnomAD missense Z: 2.38
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARRB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARRB2 as an antibody target. Whether an autoantibody or antibody against ARRB2 could matter depends on whether native ARRB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARRB2 is annotated at the cell surface, where native ARRB2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARRB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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