Seroatlas · Human Serome Atlas

CDCP1

CUB domain-containing protein 1

Also known as: CD318, CDCP1_HUMAN, SIMA135

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H5V8
Gene: CDCP1
Ensembl: ENSG00000163814
Chromosome: 3
Canonical length: 836 aa
Protein class: CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

836 residues, UniProt reviewed canonical sequence.

>Q9H5V8|CDCP1
     1  MAGLNCGVSI ALLGVLLLGA ARLPRGAEAF EIALPRESNI TVLIKLGTPT LLAKPCYIVI
    61  SKRHITMLSI KSGERIVFTF SCQSPENHFV IEIQKNIDCM SGPCPFGEVQ LQPSTSLLPT
   121  LNRTFIWDVK AHKSIGLELQ FSIPRLRQIG PGESCPDGVT HSISGRIDAT VVRIGTFCSN
   181  GTVSRIKMQE GVKMALHLPW FHPRNVSGFS IANRSSIKRL CIIESVFEGE GSATLMSANY
   241  PEGFPEDELM TWQFVVPAHL RASVSFLNFN LSNCERKEER VEYYIPGSTT NPEVFKLEDK
   301  QPGNMAGNFN LSLQGCDQDA QSPGILRLQF QVLVQHPQNE SNKIYVVDLS NERAMSLTIE
   361  PRPVKQSRKF VPGCFVCLES RTCSSNLTLT SGSKHKISFL CDDLTRLWMN VEKTISCTDH
   421  RYCQRKSYSL QVPSDILHLP VELHDFSWKL LVPKDRLSLV LVPAQKLQQH THEKPCNTSF
   481  SYLVASAIPS QDLYFGSFCP GGSIKQIQVK QNISVTLRTF APSFQQEASR QGLTVSFIPY
   541  FKEEGVFTVT PDTKSKVYLR TPNWDRGLPS LTSVSWNISV PRDQVACLTF FKERSGVVCQ
   601  TGRAFMIIQE QRTRAEEIFS LDEDVLPKPS FHHHSFWVNI SNCSPTSGKQ LDLLFSVTLT
   661  PRTVDLTVIL IAAVGGGVLL LSALGLIICC VKKKKKKTNK GPAVGIYNDN INTEMPRQPK
   721  KFQKGRKDND SHVYAVIEDT MVYGHLLQDS SGSFLQPEVD TYRPFQGTMG VCPPSPPTIC
   781  SRAPTAKLAT EEPPPRSPPE SESEPYTFSH PNNGDVSSKD TDIPLLNTQE PMEPAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDCP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

esophagus: 36 nTPM
skin: 22 nTPM
duodenum: 17 nTPM
vagina: 17 nTPM
colon: 16 nTPM
rectum: 16 nTPM

Single-cell type

ocular epithelial cells: 445 nCPM
basal keratinocytes: 311 nCPM
esophageal apical cells: 310 nCPM
suprabasal keratinocytes: 267 nCPM
esophageal suprabasal cells: 213 nCPM
esophageal basal cells: 179 nCPM

Immune cell

NK-cell: 4.2 nTPM
myeloid DC: 2.3 nTPM
neutrophil: 0.9 nTPM
classical monocyte: 0.4 nTPM
basophil: 0.2 nTPM
total PBMC: 0.2 nTPM

Brain region

choroid plexus: 27 nTPM
thalamus: 8.9 nTPM
white matter: 6.5 nTPM
medulla oblongata: 4.1 nTPM
cerebral cortex: 3.8 nTPM
pons: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: 1.37
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Spermadhesin, CUB domain superfamily
CUB domain-containing protein 1
CDCP1, third and sixth CUB domain
CDCP1, first CUB domain
CDCP1, second and fifth CUB domain
CDCP1, fourth CUB domain
CDCP1 CUB domain
CDCP1 CUB domain
CDCP1 CUB domain
CDCP1 forth CUB domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDCP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDCP1 as an antibody target. Whether an autoantibody or antibody against CDCP1 could matter depends on whether native CDCP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDCP1 is annotated at the cell surface, where native CDCP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDCP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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