Seroatlas · Human Serome Atlas

NDFIP2

NEDD4 family-interacting protein 2

Also known as: KIAA1165, N4wbp5a, NFIP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NV92
Gene: NDFIP2
Ensembl: ENSG00000102471
Chromosome: 13
Canonical length: 336 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables WW domain binding activity. Involved in negative regulation of transport and regulation of macromolecule metabolic process. Located in several cellular components, including Golgi apparatus; mitochondrion; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q9NV92|NDFIP2
     1  MARRRSQRVC ASGPSMLNSA RGAPELLRGT ATNAEVSAAA AGATGSEELP PGDRGCRNGG
    61  GRGPAATTSS TGVAVGAEHG EDSLSRKPDP EPGRMDHHQP GTGRYQVLLN EEDNSESSAI
   121  EQPPTSNPAP QIVQAASSAP ALETDSSPPP YSSITVEVPT TSDTEVYGEF YPVPPPYSVA
   181  TSLPTYDEAE KAKAAAMAAA AAETSQRIQE EECPPRDDFS DADQLRVGND GIFMLAFFMA
   241  FIFNWLGFCL SFCITNTIAG RYGAICGFGL SLIKWILIVR FSDYFTGYFN GQYWLWWIFL
   301  VLGLLLFFRG FVNYLKVRNM SESMAAAHRT RYFFLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDFIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

skin: 58 nTPM
small intestine: 56 nTPM
esophagus: 50 nTPM
duodenum: 47 nTPM
rectum: 41 nTPM
liver: 40 nTPM

Single-cell type

esophageal apical cells: 720 nCPM
late spermatids: 496 nCPM
basal keratinocytes: 404 nCPM
suprabasal keratinocytes: 334 nCPM
migrating cytotrophoblasts: 332 nCPM
early spermatids: 329 nCPM

Immune cell

eosinophil: 28 nTPM
basophil: 15 nTPM
naive CD4 T-cell: 6.3 nTPM
gdT-cell: 3.8 nTPM
T-reg: 3.8 nTPM
naive CD8 T-cell: 3.5 nTPM

Brain region

hippocampal formation: 41 nTPM
cerebral cortex: 31 nTPM
basal ganglia: 27 nTPM
white matter: 26 nTPM
pons: 15 nTPM
spinal cord: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.53
gnomAD missense Z: 0.62
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

WW domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDFIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDFIP2 as an antibody target. Whether an autoantibody or antibody against NDFIP2 could matter depends on whether native NDFIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDFIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDFIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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