Seroatlas · Human Serome Atlas

TGFB1I1

Transforming growth factor beta-1-induced transcript 1 protein

Also known as: ARA55, Hic-5, TGFI1_HUMAN, TSC-5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43294
Gene
TGFB1I1
Ensembl
ENSG00000140682
Chromosome
16
Canonical length
461 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Focal adhesion sites,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>O43294|TGFB1I1
     1  MEDLDALLSD LETTTSHMPR SGAPKERPAE PLTPPPSYGH QPQTGSGESS GASGDKDHLY
    61  STVCKPRSPK PAAPAAPPFS SSSGVLGTGL CELDRLLQEL NATQFNITDE IMSQFPSSKV
   121  ASGEQKEDQS EDKKRPSLPS SPSPGLPKAS ATSATLELDR LMASLSDFRV QNHLPASGPT
   181  QPPVVSSTNE GSPSPPEPTG KGSLDTMLGL LQSDLSRRGV PTQAKGLCGS CNKPIAGQVV
   241  TALGRAWHPE HFVCGGCSTA LGGSSFFEKD GAPFCPECYF ERFSPRCGFC NQPIRHKMVT
   301  ALGTHWHPEH FCCVSCGEPF GDEGFHEREG RPYCRRDFLQ LFAPRCQGCQ GPILDNYISA
   361  LSALWHPDCF VCRECFAPFS GGSFFEHEGR PLCENHFHAR RGSLCATCGL PVTGRCVSAL
   421  GRRFHPDHFT CTFCLRPLTK GSFQERAGKP YCQPCFLKLF G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TGFB1I1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
258 nTPM

Expression across tissuesHPA

Tissue

  • endometrium: 258 nTPM
  • colon: 251 nTPM
  • blood vessel: 231 nTPM
  • urinary bladder: 165 nTPM
  • fallopian tube: 158 nTPM
  • cervix: 128 nTPM

Single-cell type

  • megakaryocytes: 593 nCPM
  • smooth muscle cells: 439 nCPM
  • decidual stromal cells: 331 nCPM
  • breast myoepithelial cells: 280 nCPM
  • platelets: 211 nCPM
  • vascular smooth muscle cells: 202 nCPM

Immune cell

  • basophil: 9.5 nTPM
  • T-reg: 1.6 nTPM
  • total PBMC: 1.3 nTPM
  • memory B-cell: 0.9 nTPM
  • memory CD4 T-cell: 0.9 nTPM
  • naive CD8 T-cell: 0.6 nTPM

Brain region

  • medulla oblongata: 4.6 nTPM
  • thalamus: 3.4 nTPM
  • basal ganglia: 3.2 nTPM
  • pons: 3.1 nTPM
  • cerebral cortex: 3 nTPM
  • amygdala: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.03
gnomAD missense Z
1.55
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TGFB1I1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TGFB1I1 as an antibody target. Whether an autoantibody or antibody against TGFB1I1 could matter depends on whether native TGFB1I1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TGFB1I1 is annotated at the cell surface, where native TGFB1I1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TGFB1I1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TGFB1I1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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