Seroatlas · Human Serome Atlas

FASLG

Tumor necrosis factor ligand superfamily member 6

Also known as: APT1LG1, CD178, FasL, TNFL6_HUMAN, TNFSF6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48023
Gene
FASLG
Ensembl
ENSG00000117560
Chromosome
1
Canonical length
281 aa
Protein class
Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins, Transporters
Secretome location
Secreted to blood
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>P48023|FASLG
     1  MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP PPPLPPPPPP
    61  PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG MFQLFHLQKE LAELRESTSQ
   121  MHTASSLEKQ IGHPSPPPEK KELRKVAHLT GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG
   181  LVINETGLYF VYSKVYFRGQ SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA
   241  RSSYLGAVFN LTSADHLYVN VSELSLVNFE ESQTFFGLYK L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FASLG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
5.3 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 5.3 nTPM
  • spleen: 4 nTPM
  • bone marrow: 2.7 nTPM
  • lung: 1.8 nTPM
  • duodenum: 1.7 nTPM
  • tonsil: 1.7 nTPM

Single-cell type

  • nk-cells: 53 nCPM
  • t-cells: 25 nCPM
  • innate lymphoid cells: 3.5 nCPM
  • epididymal clear cells: 2 nCPM
  • mast cells: 1.3 nCPM
  • plasma cells: 0.8 nCPM

Immune cell

  • gdT-cell: 58 nTPM
  • NK-cell: 42 nTPM
  • MAIT T-cell: 36 nTPM
  • memory CD8 T-cell: 31 nTPM
  • naive CD8 T-cell: 25 nTPM
  • total PBMC: 15 nTPM

Brain region

  • white matter: 1.5 nTPM
  • medulla oblongata: 1.4 nTPM
  • midbrain: 1.4 nTPM
  • cerebral cortex: 1.3 nTPM
  • pons: 1.2 nTPM
  • basal ganglia: 1.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FASLG.

Disease | AllUniProt

Conditions FASLG is implicated in, by any mechanism.

  • Autoimmune lymphoproliferative syndrome 1B (ALPS1B) MIM:601859

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 231 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.18
gnomAD missense Z
0.58
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FASLG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FASLG as an antibody target. Whether an autoantibody or antibody against FASLG could matter depends on whether native FASLG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FASLG is annotated at the cell surface, where native FASLG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FASLG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FASLG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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