Seroatlas · Human Serome Atlas

TOM1L2

TOM1-like protein 2

Also known as: TM1L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZVM7
Gene: TOM1L2
Ensembl: ENSG00000175662
Chromosome: 17
Canonical length: 507 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Microtubules,Primary cilium,Basal body

OverviewNCBI Gene

This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

507 residues, UniProt reviewed canonical sequence.

>Q6ZVM7|TOM1L2
     1  MEFLLGNPFS TPVGQCLEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA IRALKKRLNG
    61  NRNYREVMLA LTVLETCVKN CGHRFHILVA NRDFIDSVLV KIISPKNNPP TIVQDKVLAL
   121  IQAWADAFRS SPDLTGVVHI YEELKRKGVE FPMADLDALS PIHTPQRSVP EVDPAATMPR
   181  SQSQQRTSAG SYSSPPPAPY SAPQAPALSV TGPITANSEQ IARLRSELDV VRGNTKVMSE
   241  MLTEMVPGQE DSSDLELLQE LNRTCRAMQQ RIVELISRVS NEEVTEELLH VNDDLNNVFL
   301  RYERFERYRS GRSVQNASNG VLNEVTEDNL IDLGPGSPAV VSPMVGNTAP PSSLSSQLAG
   361  LDLGTESVSG TLSSLQQCNP RDGFDMFAQT RGNSLAEQRK TVTYEDPQAV GGLASALDNR
   421  KQSSEGIPVA QPSVMDDIEV WLRTDLKGDD LEEGVTSEEF DKFLEERAKA AEMVPDLPSP
   481  PMEAPAPASN PSGRKKPERS EDALFAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOM1L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 132 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 132 nTPM
cerebral cortex: 80 nTPM
hippocampal formation: 66 nTPM
amygdala: 62 nTPM
midbrain: 58 nTPM
skeletal muscle: 57 nTPM

Single-cell type

podocytes: 920 nCPM
esophageal apical cells: 550 nCPM
urothelial cells: 419 nCPM
sertoli cells: 386 nCPM
esophageal suprabasal cells: 352 nCPM
distal convoluted tubule cells: 343 nCPM

Immune cell

neutrophil: 13 nTPM
basophil: 10 nTPM
eosinophil: 4.8 nTPM
naive CD4 T-cell: 4.3 nTPM
non-classical monocyte: 3.4 nTPM
classical monocyte: 3.3 nTPM

Brain region

pons: 219 nTPM
midbrain: 194 nTPM
medulla oblongata: 181 nTPM
thalamus: 176 nTPM
white matter: 166 nTPM
cerebral cortex: 164 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOM1L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOM1L2 as an antibody target. Whether an autoantibody or antibody against TOM1L2 could matter depends on whether native TOM1L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOM1L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOM1L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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