Seroatlas · Human Serome Atlas

KISS1R

KiSS-1 receptor

Also known as: AXOR12, GPR54, HOT7T175, KISSR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969F8
Gene
KISS1R
Ensembl
ENSG00000116014
Chromosome
19
Canonical length
398 aa
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>Q969F8|KISS1R
     1  MHTVATSGPN ASWGAPANAS GCPGCGANAS DGPVPSPRAV DAWLVPLFFA ALMLLGLVGN
    61  SLVIYVICRH KPMRTVTNFY IANLAATDVT FLLCCVPFTA LLYPLPGWVL GDFMCKFVNY
   121  IQQVSVQATC ATLTAMSVDR WYVTVFPLRA LHRRTPRLAL AVSLSIWVGS AAVSAPVLAL
   181  HRLSPGPRAY CSEAFPSRAL ERAFALYNLL ALYLLPLLAT CACYAAMLRH LGRVAVRPAP
   241  ADSALQGQVL AERAGAVRAK VSRLVAAVVL LFAACWGPIQ LFLVLQALGP AGSWHPRSYA
   301  AYALKTWAHC MSYSNSALNP LLYAFLGSHF RQAFRRVCPC APRRPRRPRR PGPSDPAAPH
   361  AELLRLGSHP APARAQKPGS SGLAARGLCV LGEDNAPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KISS1R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
3.5 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 3.5 nTPM
  • basal ganglia: 2.1 nTPM
  • pancreas: 1.3 nTPM
  • cerebral cortex: 1.2 nTPM
  • amygdala: 1.1 nTPM
  • pituitary gland: 1 nTPM

Single-cell type

  • pancreatic acinar cells: 106 nCPM
  • extravillous trophoblasts: 73 nCPM
  • other brain neurons: 8.9 nCPM
  • gonadotrophs: 7.7 nCPM
  • retinal ganglion cells: 7.7 nCPM
  • plasma cells: 7.3 nCPM

Immune cell

  • naive CD4 T-cell: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • memory B-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • hypothalamus: 19 nTPM
  • pons: 9.9 nTPM
  • cerebral cortex: 8.5 nTPM
  • basal ganglia: 7.5 nTPM
  • medulla oblongata: 7.4 nTPM
  • amygdala: 6.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KISS1R.

Disease | AllUniProt

Conditions KISS1R is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 8 with or without anosmia (HH8) MIM:614837
  • Precocious puberty, central 1 (CPPB1) MIM:176400

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 197 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypogonadotropic hypogonadism 8 without anosmia
  • KISS1R-related disorder
  • Hypogonadotropic hypogonadism 8 with or without anosmia
  • Hypogonadotropic hypogonadism
  • Central precocious puberty 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.44
gnomAD missense Z
0.89
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KISS1R in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KISS1R as an antibody target. Whether an autoantibody or antibody against KISS1R could matter depends on whether native KISS1R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KISS1R is annotated at the cell surface, where native KISS1R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KISS1R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KISS1R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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