Seroatlas · Human Serome Atlas

PNN

Pinin

Also known as: memA, PININ_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H307
Gene
PNN
Ensembl
ENSG00000100941
Chromosome
14
Canonical length
717 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in cell adhesion and mRNA splicing, via spliceosome. Predicted to act upstream of or within cell-cell adhesion. Located in exon-exon junction complex and nuclear speck. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

717 residues, UniProt reviewed canonical sequence.

>Q9H307|PNN
     1  MAVAVRTLQE QLEKAKESLK NVDENIRKLT GRDPNDVRPI QARLLALSGP GGGRGRGSLL
    61  LRRGFSDSGG GPPAKQRDLE GAVSRLGGER RTRRESRQES DPEDDDVKKP ALQSSVVATS
   121  KERTRRDLIQ DQNMDEKGKQ RNRRIFGLLM GTLQKFKQES TVATERQKRR QEIEQKLEVQ
   181  AEEERKQVEN ERRELFEERR AKQTELRLLE QKVELAQLQE EWNEHNAKII KYIRTKTKPH
   241  LFYIPGRMCP ATQKLIEESQ RKMNALFEGR RIEFAEQINK MEARPRRQSM KEKEHQVVRN
   301  EEQKAEQEEG KVAQREEELE ETGNQHNDVE IEEAGEEEEK EIAIVHSDAE KEQEEEEQKQ
   361  EMEVKMEEET EVRESEKQQD SQPEEVMDVL EMVENVKHVI ADQEVMETNR VESVEPSENE
   421  ASKELEPEME FEIEPDKECK TLSPGKENVS ALDMEKESEE KEEKESEPQP EPVAQPQPQS
   481  QPQLQLQSQS QPVLQSQPPS QPEDLSLAVL QPTPQVTQEQ GHLLPERKDF PVESVKLTEV
   541  PVEPVLTVHP ESKSKTKTRS RSRGRARNKT SKSRSRSSSS SSSSSSSTSS SSGSSSSSGS
   601  SSSRSSSSSS SSTSGSSSRD SSSSTSSSSE SRSRSRGRGH NRDRKHRRSV DRKRRDTSGL
   661  ERSHKSSKGG SSRDTKGSKD KNSRSDRKRS ISESSRSGKR SSRSERDRKS DRKDKRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
149 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 149 nTPM
  • liver: 130 nTPM
  • bone marrow: 128 nTPM
  • epididymis: 122 nTPM
  • spleen: 105 nTPM
  • pituitary gland: 92 nTPM

Single-cell type

  • epididymal principal cells: 460 nCPM
  • megakaryocyte-erythroid progenitors: 407 nCPM
  • erythrocyte progenitors: 342 nCPM
  • megakaryocyte progenitors: 281 nCPM
  • endometrial glandular cells: 277 nCPM
  • fallopian secretory cells: 253 nCPM

Immune cell

  • neutrophil: 28 nTPM
  • naive B-cell: 26 nTPM
  • memory B-cell: 22 nTPM
  • eosinophil: 22 nTPM
  • plasmacytoid DC: 22 nTPM
  • naive CD4 T-cell: 17 nTPM

Brain region

  • choroid plexus: 122 nTPM
  • hypothalamus: 65 nTPM
  • white matter: 63 nTPM
  • cerebellum: 63 nTPM
  • medulla oblongata: 58 nTPM
  • thalamus: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.11
gnomAD missense Z
0.93
DepMap mean gene effect
-0.97
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Pinin/SDK/MemA protein
  • Pinin/SDK
  • Pinin
  • pinin/SDK/memA/ protein conserved region
  • pinin/SDK conserved region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PNN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNN as an antibody target. Whether an autoantibody or antibody against PNN could matter depends on whether native PNN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNN is annotated at the cell surface, where native PNN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PNN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PNN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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