Seroatlas · Human Serome Atlas

SRCIN1

SRC kinase signaling inhibitor 1

Also known as: KIAA1684, p140Cap, SNIP, SRCN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0H9
Gene: SRCIN1
Ensembl: ENSG00000277363
Chromosome: 17
Canonical length: 1183 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cell Junctions

OverviewNCBI Gene

Enables protein kinase binding activity. Involved in several processes, including postsynaptic actin cytoskeleton organization; regulation of protein tyrosine kinase activity; and substrate adhesion-dependent cell spreading. Located in actin cytoskeleton and cytoplasm. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1183 residues, UniProt reviewed canonical sequence.

>Q9C0H9|SRCIN1
     1  MGNAPSQDPE RSSPPMLSAD DAEYPREYRT LGGGGGGGSG GRRFSNVGLV HTSERRHTVI
    61  AAQSLEALSG LQKADADRKR DAFMDHLKSK YPQHALALRG QQDRMREQPN YWSFKTRSSR
   121  HTQGAQPGLA DQAAKLSYAS AESLETMSEA ELPLGFSRMN RFRQSLPLSR SASQTKLRSP
   181  GVLFLQFGEE TRRVHITHEV SSLDTLHALI AHMFPQKLTM GMLKSPNTAI LIKDEARNVF
   241  YELEDVRDIQ DRSIIKIYRK EPLYAAFPGS HLTNGDLRRE MVYASRESSP TRRLNNLSPA
   301  PHLASGSPPP GLPSGLPSGL QSGSPSRSRL SYAGGRPPSY AGSPVHHAAE RLGGAPAAQG
   361  VSPSPSAILE RRDVKPDEDL ASKAGGMVLV KGEGLYADPY GLLHEGRLSL AAAAGDPFAY
   421  PGAGGLYKRG SVRSLSTYSA AALQSDLEDS LYKAAGGGGP LYGDGYGFRL PPSSPQKLAD
   481  VAAPPGGPPP PHSPYSGPPS RGSPVRQSFR KDSGSSSVFA ESPGGKTRSA GSASTAGAPP
   541  SELFPGPGER SLVGFGPPVP AKDTETRERM EAMEKQIASL TGLVQSALLR GSEPETPSEK
   601  IEGSNGAATP SAPCGSGGRS SGATPVSGPP PPSASSTPAG QPTAVSRLQM QLHLRGLQNS
   661  ASDLRGQLQQ LRKLQLQNQE SVRALLKRTE AELSMRVSEA ARRQEDPLQR QRTLVEEERL
   721  RYLNDEELIT QQLNDLEKSV EKIQRDVSHN HRLVPGPELE EKALVLKQLG ETLTELKAHF
   781  PGLQSKMRVV LRVEVEAVKF LKEEPQRLDG LLKRCRGVTD TLAQIRRQVD EGVWPPPNNL
   841  LSQSPKKVTA ETDFNKSVDF EMPPPSPPLN LHELSGPAEG ASLTPKGGNP TKGLDTPGKR
   901  SVDKAVSVEA AERDWEEKRA ALTQYSAKDI NRLLEETQAE LLKAIPDLDC ASKAHPGPAP
   961  TPDHKPPKAP HGQKAAPRTE PSGRRGSDEL TVPRYRTEKP SKSPPPPPPR RSFPSSHGLT
  1021  TTRTGEVVVT SKKDSAFIKK AESEELEVQK PQVKLRRAVS EVARPASTPP IMASAIKDED
  1081  DEDRIIAELE SGGGSVPPMK VVTPGASRLK AAQGQAGSPD KSKHGKQRAE YMRIQAQQQA
  1141  TKPSKEMSGS NETSSPVSEK PSASRTSIPV LTSFGARNSS ISF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRCIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 77 nTPM
cerebellum: 69 nTPM
midbrain: 49 nTPM
hippocampal formation: 46 nTPM
hypothalamus: 31 nTPM
amygdala: 31 nTPM

Single-cell type

oligodendrocytes: 353 nCPM
brain excitatory neurons: 100 nCPM
ependymal cells: 65 nCPM
brain inhibitory neurons: 61 nCPM
other brain neurons: 59 nCPM
renal collecting duct principal cells: 19 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 168 nTPM
cerebral cortex: 114 nTPM
medulla oblongata: 113 nTPM
pons: 107 nTPM
basal ganglia: 102 nTPM
thalamus: 98 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 2.82
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRCIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRCIN1 as an antibody target. Whether an autoantibody or antibody against SRCIN1 could matter depends on whether native SRCIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRCIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRCIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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