Seroatlas · Human Serome Atlas

CAV2

Caveolin-2

Also known as: CAV, CAV2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51636
Gene
CAV2
Ensembl
ENSG00000105971
Chromosome
7
Canonical length
162 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

162 residues, UniProt reviewed canonical sequence.

>P51636|CAV2
     1  MGLETEKADV QLFMDDDSYS HHSGLEYADP EKFADSDQDR DPHRLNSHLK LGFEDVIAEP
    61  VTTHSFDKVW ICSHALFEIS KYVMYKFLTV FLAIPLAFIA GILFATLSCL HIWILMPFVK
   121  TCLMVLPSVQ TIWKSVTDVI IAPLCTSVGR CFSSVSLQLS QD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAV2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
213 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 213 nTPM
  • lung: 152 nTPM
  • heart muscle: 143 nTPM
  • thyroid gland: 102 nTPM
  • blood vessel: 89 nTPM
  • placenta: 88 nTPM

Single-cell type

  • cardiomyocytes: 1,402 nCPM
  • adipocytes: 1,031 nCPM
  • alveolar cells type 1: 798 nCPM
  • basal keratinocytes: 417 nCPM
  • vascular smooth muscle cells: 371 nCPM
  • transitional alveolar cells: 264 nCPM

Immune cell

  • basophil: 97 nTPM
  • neutrophil: 0.8 nTPM
  • total PBMC: 0.5 nTPM
  • eosinophil: 0.4 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • memory B-cell: 0.1 nTPM

Brain region

  • thalamus: 17 nTPM
  • white matter: 16 nTPM
  • medulla oblongata: 16 nTPM
  • pons: 15 nTPM
  • spinal cord: 15 nTPM
  • basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0.03
gnomAD missense Z
0.04
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAV2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAV2 as an antibody target. Whether an autoantibody or antibody against CAV2 could matter depends on whether native CAV2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAV2 is annotated at the cell surface, where native CAV2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CAV2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAV2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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