TRAP1

Protein identityUniProt · HPA

UniProt accession

Q12931

Gene

TRAP1

Ensembl

ENSG00000126602

Chromosome

16

Canonical length

704 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

704 residues, UniProt reviewed canonical sequence.

>Q12931|TRAP1
     1  MARELRALLL WGRRLRPLLR APALAAVPGG KPILCPRRTT AQLGPRRNPA WSLQAGRLFS
    61  TQTAEDKEEP LHSIISSTES VQGSTSKHEF QAETKKLLDI VARSLYSEKE VFIRELISNA
   121  SDALEKLRHK LVSDGQALPE MEIHLQTNAE KGTITIQDTG IGMTQEELVS NLGTIARSGS
   181  KAFLDALQNQ AEASSKIIGQ FGVGFYSAFM VADRVEVYSR SAAPGSLGYQ WLSDGSGVFE
   241  IAEASGVRTG TKIIIHLKSD CKEFSSEARV RDVVTKYSNF VSFPLYLNGR RMNTLQAIWM
   301  MDPKDVREWQ HEEFYRYVAQ AHDKPRYTLH YKTDAPLNIR SIFYVPDMKP SMFDVSRELG
   361  SSVALYSRKV LIQTKATDIL PKWLRFIRGV VDSEDIPLNL SRELLQESAL IRKLRDVLQQ
   421  RLIKFFIDQS KKDAEKYAKF FEDYGLFMRE GIVTATEQEV KEDIAKLLRY ESSALPSGQL
   481  TSLSEYASRM RAGTRNIYYL CAPNRHLAEH SPYYEAMKKK DTEVLFCFEQ FDELTLLHLR
   541  EFDKKKLISV ETDIVVDHYK EEKFEDRSPA AECLSEKETE ELMAWMRNVL GSRVTNVKVT
   601  LRLDTHPAMV TVLEMGAARH FLRMQQLAKT QEERAQLLQP TLEINPRHAL IKKLNQLRAS
   661  EPGLAQLLVD QIYENAMIAA GLVDDPRAMV GRLNELLVKA LERH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

182 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAP1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 522 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Congenital anomalies of kidney and urinary tract 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.41

gnomAD pLI

0

gnomAD missense Z

-2.72

DepMap mean gene effect

-0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of cellular respiration
• negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
• negative regulation of reactive oxygen species biosynthetic process
• protein folding
• translational attenuation

Molecular functions

• ATP binding
• ATP hydrolysis activity
• ATP-dependent protein folding chaperone
• protein kinase binding
• RNA binding
• tumor necrosis factor receptor binding
• unfolded protein binding

Cellular components

• membrane
• mitochondrial inner membrane
• mitochondrial intermembrane space
• mitochondrial matrix
• mitochondrion
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Heat shock protein Hsp90 family
• Histidine kinase/HSP90-like ATPase domain
• Ribosomal protein uS5 domain 2-type superfamily
• Heat shock protein Hsp90, N-terminal
• Histidine kinase/HSP90-like ATPase superfamily
• HSP90, C-terminal domain
• Hsp90 protein
• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

KeywordsUniProt

• Acetylation
• ATP-binding
• Chaperone
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Nucleotide-binding
• Phosphoprotein
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of TRAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SDHA
• SRC
• FKBP5
• HSD17B10