Seroatlas · Human Serome Atlas

RALGPS1

Ras-specific guanine nucleotide-releasing factor RalGPS1

Also known as: KIAA0351, RALGEF2, RALGPS1A, RGPS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5JS13
Gene
RALGPS1
Ensembl
ENSG00000136828
Chromosome
9
Canonical length
557 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity. Involved in regulation of Ral protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

557 residues, UniProt reviewed canonical sequence.

>Q5JS13|RALGPS1
     1  MYKRNGLMAS VLVTSATPQG SSSSDSLEGQ SCDYASKSYD AVVFDVLKVT PEEFASQITL
    61  MDIPVFKAIQ PEELASCGWS KKEKHSLAPN VVAFTRRFNQ VSFWVVREIL TAQTLKIRAE
   121  ILSHFVKIAK KLLELNNLHS LMSVVSALQS APIFRLTKTW ALLNRKDKTT FEKLDYLMSK
   181  EDNYKRTREY IRSLKMVPSI PYLGIYLLDL IYIDSAYPAS GSIMENEQRS NQMNNILRII
   241  ADLQVSCSYD HLTTLPHVQK YLKSVRYIEE LQKFVEDDNY KLSLRIEPGS SSPRLVSSKE
   301  DLAGPSAGSG SARFSRRPTC PDTSVAGSLP TPPVPRHRKS HSLGNNMMCQ LSVVESKSAT
   361  FPSEKARHLL DDSVLESRSP RRGLALTSSS AVTNGLSLGS SESSEFSEEM SSGLESPTGP
   421  CICSLGNSAA VPTMEGPLRR KTLLKEGRKP ALSSWTRYWV ILSGSTLLYY GAKSLRGTDR
   481  KHYKSTPGKK VSIVGWMVQL PDDPEHPDIF QLNNPDKGNV YKFQTGSRFH AILWHKHLDD
   541  ACKSNRPQVP ANLMSFE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RALGPS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 37 nTPM
  • duodenum: 29 nTPM
  • retina: 29 nTPM
  • small intestine: 27 nTPM
  • spinal cord: 22 nTPM
  • pituitary gland: 18 nTPM

Single-cell type

  • thyrotrophs: 347 nCPM
  • rod photoreceptor cells: 322 nCPM
  • gonadotrophs: 320 nCPM
  • epicardial cells: 305 nCPM
  • renal collecting duct intercalated cells: 298 nCPM
  • retinal ganglion cells: 290 nCPM

Immune cell

  • memory B-cell: 2.3 nTPM
  • neutrophil: 0.9 nTPM
  • NK-cell: 0.8 nTPM
  • eosinophil: 0.7 nTPM
  • naive B-cell: 0.7 nTPM
  • plasmacytoid DC: 0.7 nTPM

Brain region

  • white matter: 63 nTPM
  • pons: 62 nTPM
  • medulla oblongata: 59 nTPM
  • cerebellum: 58 nTPM
  • thalamus: 54 nTPM
  • cerebral cortex: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.13
gnomAD pLI
1
gnomAD missense Z
3.09
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RALGPS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RALGPS1 as an antibody target. Whether an autoantibody or antibody against RALGPS1 could matter depends on whether native RALGPS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RALGPS1 is annotated at the cell surface, where native RALGPS1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RALGPS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RALGPS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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